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9-Methoxycanthin-6-one
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Catalog No. T4601Cas No. 74991-91-6
9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.
9-Methoxycanthin-6-one
Copy Product Info🥰Excellent
Purity: 99.61%
Catalog No. T4601Cas No. 74991-91-6
9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $67 | In Stock | In Stock | |
| 5 mg | $163 | In Stock | In Stock | |
| 10 mg | $263 | In Stock | In Stock | |
| 25 mg | $497 | In Stock | In Stock | |
| 50 mg | $739 | In Stock | In Stock | |
| 100 mg | $987 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $178 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.61%
Appearance:Solid
Color:White
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Product Introduction
9-Methoxycanthin-6-one AI Summary
9-Methoxycanthin-6-one exhibits significant cytotoxic activity against a variety of cancer cell lines, demonstrating potential anti-cancer properties. Specifically, it shows strong cytotoxicity against human KB cells, human breast cancer cells (such as MCF7), human A549 lung cancer cells, and mouse P388 cells, with ED50 values ranging from 1.4 to 4.5 µg/mL. Additionally, it inhibits NF-kappaB activity in TNF-alpha stimulated human HEK-293/NF-kB-luc cells, with an IC50 of 7400 nM and greater than 50% inhibition at 30 µM. The compound also demonstrates bioactivity by inhibiting PTP1B with a 34.9% inhibition rate at 100 µM. Moreover, 9-Methoxycanthin-6-one exhibits antiviral activity against HCoV-OC43 in human HCT-8 cells at 10 µM, despite higher CC50 values in several non-cancerous cell lines such as African green monkey Vero cells and human Calu-3, MRC5, and HepG2 cells. This broad spectrum of activity highlights its potential for development in cancer therapy and antiviral applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL. |
| Molecular Weight | 250.25 |
| Formula | C15H10N2O2 |
| Cas No. | 74991-91-6 |
| Smiles | COc1ccc2c3ccnc4ccc(=O)n(c2c1)c34 |
| Relative Density. | 1.40 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (15.98 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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