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Molecular Glues

Molecular glue refers to a class of chemical compounds or molecules that play a crucial role in binding and stabilizing protein-protein interactions in biological systems. These molecules act as "glue" by enhancing the affinity between proteins, ultimately influencing various cellular processes. Molecular glue compounds have gained significant attention in the fields of drug discovery, chemical biology, and fundamental research due to their potential to modulate protein interactions, and thus, impact various cellular pathways. They have unlocked avenues in medicine previously thought to be “undruggable.”

  • Mezigdomide
    T107032259648-80-9In house
    Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
    • $118
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  • Lenalidomide
    T1642191732-72-6
    Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
    • $36
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    TargetMol | Citations Cited
  • PT-179
    T843012924858-25-1
    PT-179 is a novel IMiD derivative, a molecular gel.
    • $52
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  • dCeMM1
    T67778118719-16-7
    dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells.
    • $32
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  • Naphthyridine carbamate dimer
    T81705864627-58-7
    Naphthyridine carbamate dimer (NCD) acts as a molecular glue for DNA, facilitating specific structural alterations within targeted functional DNA sequences to modulate their activity [1].
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  • Antitumor agent-100 hydrochloride
    T791382841750-53-4
    Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].
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  • HQ461
    T98491226443-41-9
    HQ461 is a molecular gel that promotes CDK12-DDB1 interactions and triggers cyclin K degradation, which impairs CDK12 function, leading to decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
    • $38
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  • dCeMM2
    T61477296771-07-8
    dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.
    • $31
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  • FPFT-2216
    T606082367619-87-0
    FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.FPFT-2216 has potential antitumor activity and can be used to study diseases of the immune system.FPFT-2216 is a molecular gel that degrades IKZF6, IKZF1, DE1D, and CK3α.
    • $98
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  • Thalidomide
    T021350-35-1
    Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
    • $50
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    TargetMol | Citations Cited
  • Lenalidomide hemihydrate
    T22922847871-99-2
    Lenalidomide hemihydrate is a derivative of Thalidomide, an orally active immunomodulator that acts as a molecular gel. It is a ligand for the ubiquitin E3 ligase cereblon, which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase.
    • $29
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  • Eragidomide
    T107651860875-51-9
    Dicyclanil is an insect growth regulator with a chemical structure similar to that of cyclopromazine.
    • $34
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  • Pomalidomide
    T238419171-19-8
    Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
    • $52
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