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3-chloro-5-hydroxybenzoic Acid

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Catalog No. T7482Cas No. 53984-36-4

3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)

3-chloro-5-hydroxybenzoic Acid

3-chloro-5-hydroxybenzoic Acid

😃Good
Purity: 98%
Catalog No. T7482Cas No. 53984-36-4
3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$34In StockIn Stock
100 mg$44In StockIn Stock
200 mg$64BackorderBackorder
1 mL x 10 mM (in DMSO)$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)
In vivo
3-chloro-5-hydroxybenzoic Acid is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks[1]
Chemical Properties
Molecular Weight172.57
FormulaC7H5ClO3
Cas No.53984-36-4
SmilesOC(=O)C1=CC(Cl)=CC(O)=C1
Relative Density.1.536 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 34 mg/mL (197.02 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.7947 mL28.9737 mL57.9475 mL289.7375 mL
5 mM1.1589 mL5.7947 mL11.5895 mL57.9475 mL
10 mM0.5795 mL2.8974 mL5.7947 mL28.9737 mL
20 mM0.2897 mL1.4487 mL2.8974 mL14.4869 mL
50 mM0.1159 mL0.5795 mL1.1589 mL5.7947 mL
100 mM0.0579 mL0.2897 mL0.5795 mL2.8974 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

obesitynonesterified free fatty acidlactate receptorInhibitorinhibitGPR81cholesterol3-chloro-5-hydroxybenzoic Acid3chloro5hydroxybenzoic Acid3 chloro 5 hydroxybenzoic Acid
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