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VGSC blocker-1

Catalog No. T39717 CAS 2230472-55-4

VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.

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VGSC blocker-1, CAS 2230472-55-4

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

VGSC blocker 1 (compound 1), at concentrations ranging from 1.0 to 10 μM, effectively inhibits the human breast cancer cell line MDA-MB-231[1]. Specifically, this compound reduces cell viability and impacts cell invasion within this cell line. Experimental results demonstrate that VGSC blocker 1 decreases INa peak currents by 34.9% at a concentration of 1 µM, alongside a marginal 0.3% inhibition of cell invasion at the same concentration. These effects surpass the efficacy thresholds previously established at 0.1 µM for significant nNav1.5 current blockade and 1 µM for cell invasion inhibition, underscoring the compound's potent biological activity against MDA-MB-231 cells.

Molecular Weight	386.531
Formula	C24H32F2N2
CAS No.	2230472-55-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dutta S, et al. Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells. Bioorg Med Chem. 2018;26(9):2428-2436.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VGSC blocker-1 2230472-55-4 VGSC blocker 1 VGSC blocker1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.