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Fingolimod

Name: Fingolimod
Brand: TargetMol
SKU: T7939
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7939Cas No. 162359-55-9

Alias FTY-720A, FTY-720

Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

Fingolimod

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Purity: 99.6%

Catalog No. T7939Alias FTY-720A, FTY-720Cas No. 162359-55-9

Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$37	In Stock	In Stock
100 mg	$50	In Stock	In Stock
500 mg	$126	In Stock	-
1 g	$158	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
Targets&IC50	S1P1:0.033 nM
In vitro	Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin.?Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth.?Additionally, Fingolimod significantly reduces LPA levels in the injured nerve.?PF-8380 treatment correlates with improved myelin thickness[1]
Cell Research	Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1].
Synonyms	FTY-720A, FTY-720

Chemical Properties

Molecular Weight	307.47
Formula	C₁₉H₃₃NO₂
Cas No.	162359-55-9
Smiles	CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
Relative Density.	1.016 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 30 mg/mL (97.57 mM), Sonication is recommended.

Ethanol: 7.69 mg/mL (25.01 mM), Sonication is recommended.

DMSO: 1 mg/mL (3.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol/Methanol

	1mg	5mg	10mg	50mg
1 mM	3.2523 mL	16.2617 mL	32.5235 mL	162.6175 mL

Ethanol/Methanol

	1mg	5mg	10mg	50mg
5 mM	0.6505 mL	3.2523 mL	6.5047 mL	32.5235 mL
10 mM	0.3252 mL	1.6262 mL	3.2523 mL	16.2617 mL
20 mM	0.1626 mL	0.8131 mL	1.6262 mL	8.1309 mL

Methanol

	1mg	5mg	10mg	50mg
50 mM	0.0650 mL	0.3252 mL	0.6505 mL	3.2523 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc