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YHO-13351

Name: YHO-13351
Brand: TargetMol
SKU: T13366
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13366Cas No. 1346753-00-1

Alias YHO13351, YHO 13351

YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem/initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.

YHO-13351

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Purity: 97.88%

Catalog No. T13366Alias YHO13351, YHO 13351Cas No. 1346753-00-1

YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem/initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$106	In Stock
25 mg	$176	In Stock

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Purity:97.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem/initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.
In vitro	In the presence of YHO-13351 (0-0.1 μM), HeLa cells stained with Hoechst dye were analyzed by flow cytometry using a fluorescence-activated cell sorter, which revealed that YHO-13177 is capable of reducing the SP fraction score [2].
In vivo	When used in combination with irinotecan, YHO-13351 reduces the increase in the ratio of SP cells in tumors compared to treatment with irinotecan alone[2].
Synonyms	YHO13351, YHO 13351

Chemical Properties

Molecular Weight	579.73
Formula	C₂₇H₃₇N₃O₇S₂
Cas No.	1346753-00-1
Smiles	S(C)(=O)(=O)O.C(=C(\C#N)/C1=CC(OC)=C(OC)C=C1)\C=2SC(=CC2)N3CCC(OC(CN(CC)CC)=O)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (276.00 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7249 mL	8.6247 mL	17.2494 mL	86.2470 mL
5 mM	0.3450 mL	1.7249 mL	3.4499 mL	17.2494 mL
10 mM	0.1725 mL	0.8625 mL	1.7249 mL	8.6247 mL
20 mM	0.0862 mL	0.4312 mL	0.8625 mL	4.3124 mL
50 mM	0.0345 mL	0.1725 mL	0.3450 mL	1.7249 mL
100 mM	0.0172 mL	0.0862 mL	0.1725 mL	0.8625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc