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YHO-13351

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Catalog No. T13366Cas No. 1346753-00-1

Alias YHO13351, YHO 13351

YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem/initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.

YHO-13351

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Purity: 97.88%

Catalog No. T13366Alias YHO13351, YHO 13351Cas No. 1346753-00-1

YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem/initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$106	-	In Stock
25 mg	$176	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.88%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem/initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.
In vitro	In the presence of YHO-13351 (0-0.1 μM), HeLa cells stained with Hoechst dye were analyzed by flow cytometry using a fluorescence-activated cell sorter, which revealed that YHO-13177 is capable of reducing the SP fraction score [2].
In vivo	When used in combination with irinotecan, YHO-13351 reduces the increase in the ratio of SP cells in tumors compared to treatment with irinotecan alone[2].
Synonyms	YHO13351, YHO 13351

Chemical Properties

Molecular Weight	579.73
Formula	C₂₇H₃₇N₃O₇S₂
Cas No.	1346753-00-1
Smiles	S(C)(=O)(=O)O.C(=C(\C#N)/C1=CC(OC)=C(OC)C=C1)\C=2SC(=CC2)N3CCC(OC(CN(CC)CC)=O)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (275.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7249 mL	8.6247 mL	17.2494 mL	86.2470 mL
5 mM	0.3450 mL	1.7249 mL	3.4499 mL	17.2494 mL
10 mM	0.1725 mL	0.8625 mL	1.7249 mL	8.6247 mL
20 mM	0.0862 mL	0.4312 mL	0.8625 mL	4.3124 mL
50 mM	0.0345 mL	0.1725 mL	0.3450 mL	1.7249 mL
100 mM	0.0172 mL	0.0862 mL	0.1725 mL	0.8625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc