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AMP-PCP disodium

Name: AMP-PCP disodium
Brand: TargetMol
SKU: T13547L
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13547LCas No. 7414-56-4

AMP-PCP disodium, an ATP analogue, binds to the N-terminal domain of Hsp90 with a Kd value of 3.8 μM, facilitating the formation of an active Hsp90 homodimer.

AMP-PCP disodium

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Purity: 99.32%

Catalog No. T13547LCas No. 7414-56-4

AMP-PCP disodium, an ATP analogue, binds to the N-terminal domain of Hsp90 with a Kd value of 3.8 μM, facilitating the formation of an active Hsp90 homodimer.

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$236	In Stock
25 mg	$397	In Stock

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Purity:99.32%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	AMP-PCP disodium, an ATP analogue, binds to the N-terminal domain of Hsp90 with a Kd value of 3.8 μM, facilitating the formation of an active Hsp90 homodimer.
Targets&IC50	HSP90:3.8 μM (kd)
In vitro	Under the promotion of AMP-PCP disodium binding, the formation of Hsp135 active homodimers was enhanced by promoting the characteristic slow-effect conformational exchange of cap region ( A90-G117 ) and surrounding region residues ( A141-A111 ). A total of 90 non-proline residues were identified in the triple-labeled Hsp170 and AMP-PCP binding [ 1 ].

Chemical Properties

Molecular Weight	549.17
Formula	C₁₁H₁₆N₅Na₂O₁₂P₃
Cas No.	7414-56-4
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(CP([O-])([O-])=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.[Na+].[Na+]
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (145.67 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.8209 mL	9.1046 mL	18.2093 mL	91.0465 mL
5 mM	0.3642 mL	1.8209 mL	3.6419 mL	18.2093 mL
10 mM	0.1821 mL	0.9105 mL	1.8209 mL	9.1046 mL
20 mM	0.0910 mL	0.4552 mL	0.9105 mL	4.5523 mL
50 mM	0.0364 mL	0.1821 mL	0.3642 mL	1.8209 mL
100 mM	0.0182 mL	0.0910 mL	0.1821 mL	0.9105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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