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Latanoprostene bunod

Name: Latanoprostene bunod
Brand: TargetMol
SKU: T15719
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15719Cas No. 860005-21-6

Alias NCX116, LBN

Latanoprostene bunod (LBN) is nitric oxide (NO)-donating prostaglandin F2a analog and is a topical ophthalmic therapeutic. It is used for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT).

Latanoprostene bunod

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Purity: 99.69%

Catalog No. T15719Alias NCX116, LBNCas No. 860005-21-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	-
5 mg	$189	In Stock	-
10 mg	$297	In Stock	-
25 mg	$492	In Stock	-
50 mg	$717	In Stock	-
100 mg	$988	In Stock	-
200 mg	$1,330	Inquiry	Inquiry
500 mg	$1,980	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$209	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Oil

Color:Transparent

Resource Download

COA HPLC HNMR

Product Introduction

Latanoprostene bunod AI Summary

Latanoprostene bunod exhibits a broad spectrum of bioactivities with relatively weak binding affinity and inhibition activities. It has a half-life of 1.8 hours in rabbits. The compound interacts with various human receptors and enzymes, including but not limited to DRD1, SLC6A3, ADORA1, and Gabra1, with most binding affinity (AC50) values being greater than 30,000.0 nM. It shows moderate to weak inhibition against enzymes like ACHE, MAOA, and PDE3A, with AC50 values also above 30,000.0 nM, except for PTGS1 inhibition measured by fluorescence, which has an AC50 of 13,489.9 nM. Additionally, the compound displays antagonist and agonist activities at some receptors, notably TBXA2R and ADRA1A, with AC50 values just over 10,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Latanoprostene bunod (LBN) is nitric oxide (NO)-donating prostaglandin F2a analog and is a topical ophthalmic therapeutic. It is used for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT).
Synonyms	NCX116, LBN

Chemical Properties

Molecular Weight	507.62
Formula	C₂₇H₄₁NO₈
Cas No.	860005-21-6
Smiles	O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCCCCO[N+]([O-])=O)CCc1ccccc1
Relative Density.	1.178 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (197 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9700 mL	9.8499 mL	19.6998 mL	98.4989 mL
5 mM	0.3940 mL	1.9700 mL	3.9400 mL	19.6998 mL
10 mM	0.1970 mL	0.9850 mL	1.9700 mL	9.8499 mL
20 mM	0.0985 mL	0.4925 mL	0.9850 mL	4.9249 mL
50 mM	0.0394 mL	0.1970 mL	0.3940 mL	1.9700 mL
100 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.9850 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc