Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM. The compound potently suppresses proliferation in FLT3-ITD-positive cells, reduces phosphorylation levels of FLT3 and STAT5, and demonstrates inhibition of tumor growth in murine leukemia models [1].
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Description | PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM. The compound potently suppresses proliferation in FLT3-ITD-positive cells, reduces phosphorylation levels of FLT3 and STAT5, and demonstrates inhibition of tumor growth in murine leukemia models [1]. |
Molecular Weight | 969.97 |
Formula | C46H50F3N13O8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PF15 TFA PROTAC PROTACs inhibitor inhibit