BMS-1166 hydrochloride

Name: BMS-1166 hydrochloride
Brand: TargetMol
SKU: T14670
Rating: 4.5 (1 reviews)

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Catalog No. T14670Cas No. 2113650-05-6

Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). BMS-1166 hydrochloride is an inhibitor of PD-1/PD-L1 interaction (IC50: 1.4 nM). BMS-1166 rivalries the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

BMS-1166 hydrochloride

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Catalog No. T14670Cas No. 2113650-05-6

Pack Size	Price	Availability	Quantity
1 mg	$223	35 days
10 mg	$1,720	35 days

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Product Introduction

Bioactivity

Description	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). BMS-1166 hydrochloride is an inhibitor of PD-1/PD-L1 interaction (IC50: 1.4 nM). BMS-1166 rivalries the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
Targets&IC50	PD-1/PD-L1:1.4 nM
In vitro	BMS-1166 is a potent inhibitor of PD-1/PD-L1 interaction, showing an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1] and dose-dependently abolishing the inhibition of ECs stimulation by sPD-L1[2].

Chemical Properties

Molecular Weight	677.57
Formula	C₃₆H₃₄Cl₂N₂O₇
Cas No.	2113650-05-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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