Shopping Cart

Your shopping cart is currently empty

PD-1/PD-L1-IN-9

Name: PD-1/PD-L1-IN-9
Brand: TargetMol
SKU: T9651
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9651Cas No. 2628506-54-5

PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.

PD-1/PD-L1-IN-9

🥰Excellent

Purity: 99.92%

Catalog No. T9651Cas No. 2628506-54-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
2 mg	$82	In Stock	In Stock
5 mg	$136	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$331	In Stock	In Stock
50 mg	$451	-	In Stock
100 mg	$595	-	In Stock
500 mg	$1,180	-	In Stock
1 mL x 10 mM (in DMSO)	$151	In Stock	In Stock

Add to Cart

Add to Quotation

Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.92%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
In vitro	PD-1/PD-L1-IN-9 (46.9-1500 nM; pretreated for 2 h) enhances the antitumor immunity of PBMCs against MDB-MB 231 cells in a dose-dependent manner, with an EC50 of approximately 100 nM[1].
In vivo	PD-1/PD-L1-IN-9 (40-80 mg/kg; p.o. once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner without causing body weight loss or mortality in mice. PD-1/PD-L1-IN-9 (3 mg/kg; a single i.v.) exhibits a half-life (t1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg), and Cmax (1233 ng/mL) in rats. PD-1/PD-L1-IN-9 (25 mg/kg; a single p.o.) shows moderate oral bioavailability (F=22%), half-life (t1/2=6.4 h), and Cmax (192 ng/mL) in rats[1].

Chemical Properties

Molecular Weight	348.44
Formula	C₂₂H₂₄N₂O₂
Cas No.	2628506-54-5
Smiles	COc1nc(ccc1CNCCO)-c1cccc(c1C)-c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (258.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8699 mL	14.3497 mL	28.6993 mL	143.4967 mL
5 mM	0.5740 mL	2.8699 mL	5.7399 mL	28.6993 mL
10 mM	0.2870 mL	1.4350 mL	2.8699 mL	14.3497 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1748 mL
50 mM	0.0574 mL	0.2870 mL	0.5740 mL	2.8699 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4350 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc