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PD-1/PD-L1-IN-9

Catalog No. T9651   CAS 2628506-54-5

PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.

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PD-1/PD-L1-IN-9 Chemical Structure
PD-1/PD-L1-IN-9, CAS 2628506-54-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 55.00
2 mg In stock $ 82.00
5 mg In stock $ 136.00
10 mg In stock $ 198.00
25 mg In stock $ 331.00
50 mg In stock $ 451.00
100 mg In stock $ 595.00
500 mg In stock $ 1,180.00
1 mL * 10 mM (in DMSO) In stock $ 151.00
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Purity: 99.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
In vitro PD-1/PD-L1-IN-9 (46.9-1500 nM; pretreated for 2 h) dose-dependently significantly activates the antitumor immunity of PBMCs to MDB-MB 231 cells, EC50 = ∼100 nM[1].
In vivo PD-1/PD-L1-IN-9 (40-80 mg/kg; p.o. once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice. PD-1/PD-L1-IN-9 (3 mg/kg; a single i.v.) exhibits half-life (t1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg) and Cmax (1233 ng/mL) in rats. PD-1/PD-L1-IN-9 (25 mg/kg; a single p.o.) exhibits moderate oral bioavailability (F=22 %), half-life (t1/2=6.4 h) and Cmax (192 ng/mL) in rats[1].
Molecular Weight 348.44
Formula C22H24N2O2
CAS No. 2628506-54-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (258.3 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Immuno-Oncology Compound Library Anti-Ovarian Cancer Compound Library PPI Inhibitor Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max

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Keywords

PD-1/PD-L1-IN-9 2628506-54-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 PD1/PDL1IN9 PD 1/PD L1 IN 9 inhibitor inhibit

 

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