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PD-1/PD-L1-IN-9

Catalog No. T9651 CAS 2628506-54-5

<a href="/target/PD_1_PD_L1" style="display: inline; color: #c13a36">PD-1/PD-L1</a>-IN-9 is a potent and orally active inhibitor of <a href="/target/PD_1_PD_L1" style="display: inline; color: #c13a36">PD-1/PD-L1</a> interaction, IC50 = 3.8 nM. <a href="/target/PD_1_PD_L1" style="display: inline; color: #c13a36">PD-1/PD-L1</a>-IN-9 can enhance the killing activity of tumor cells by immune cells. <a href="/target/PD_1_PD_L1" style="display: inline; color: #c13a36">PD-1/PD-L1</a>-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model.

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PD-1/PD-L1-IN-9, CAS 2628506-54-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 159.00
2 mg	In stock	$ 238.00
5 mg	In stock	$ 317.00
10 mg	In stock	$ 527.00
25 mg	In stock	$ 995.00
50 mg	In stock	$ 1,535.00
100 mg	In stock	$ 2,255.00

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Purity: 99.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, IC50 = 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model.
In vitro	PD-1/PD-L1-IN-9 (46.9-1500 nM; pretreated for 2 h) dose-dependently significantly activates the antitumor immunity of PBMCs to MDB-MB 231 cells, EC50 = ∼100 nM[1].
In vivo	PD-1/PD-L1-IN-9 (40-80 mg/kg; p.o. once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice. PD-1/PD-L1-IN-9 (3 mg/kg; a single i.v.) exhibits half-life (t1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg) and Cmax (1233 ng/mL) in rats. PD-1/PD-L1-IN-9 (25 mg/kg; a single p.o.) exhibits moderate oral bioavailability (F=22 %), half-life (t1/2=6.4 h) and Cmax (192 ng/mL) in rats[1].

Molecular Weight	348.446
Formula	C22H24N2O2
CAS No.	2628506-54-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90 mg/mL (258.3 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Inhibitor Library

Related Products

Related compounds with same targets

AUNP-12 acetate Pembrolizumab Nivolumab Avelumab Atezolizumab PD-1/PD-L1-IN-10 PD-1/PD-L1-IN-NP19 Spartalizumab (anti-PD-1)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PD-1/PD-L1-IN-9 2628506-54-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 PD1/PDL1IN9 PD 1/PD L1 IN 9 Inhibitor inhibitor inhibit

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