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Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738)
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Catalog No. TMAY-01658
Alias STAT6C, STAT6B, Stat6 (p-Y641), Stat6 (p-Tyr641), STAT-6, p-Stat6 (Y641), p-Stat6 (Tyr641), Phospho-Stat6 (Y641), IL-4-STAT, HIES6, D12S1644
Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738) is a Rabbit antibody targeting Phospho-Stat6 (Tyr641). Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738) can be used in WB.
Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738)
Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738)
😃Good
Catalog No. TMAY-01658Alias STAT6C, STAT6B, Stat6 (p-Y641), Stat6 (p-Tyr641), STAT-6, p-Stat6 (Y641), p-Stat6 (Tyr641), Phospho-Stat6 (Y641), IL-4-STAT, HIES6, D12S1644
Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738) is a Rabbit antibody targeting Phospho-Stat6 (Tyr641). Anti-Phospho-Stat6 (Tyr641) Antibody (6Y738) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $80 | 7-10 days | |
| 100 μL | $233 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB Reactivity: Human |
| Alias | STAT6C, STAT6B, Stat6 (p-Y641), Stat6 (p-Tyr641), STAT-6, p-Stat6 (Y641), p-Stat6 (Tyr641), Phospho-Stat6 (Y641), IL-4-STAT, HIES6, D12S1644 |
| Ig Type | Rabbit IgG |
| Clone | 6Y738 |
| Reactivity | Human;
Species predicted to react based on 100% sequence homology: Cynomolgus, Bovin, Pig, Chicken |
| Verified Activity | 1. Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with IL4 (100 ng/mL, 15min; +), using Phospho-Stat6 (Tyr641) Antibody, Rabbit MAb at 1:10000 dilution (upper) or Anti-STAT6 Antibody, Rabbit PAb at 1:1000 dilution (lower). 2. Western blot analysis of extracts from serum-starved Hela, treated with IL4 (100 ng/mL, 15 min), using Phospho-Stat6 (Tyr641) Antibody, Rabbit MAb and other brands’ antibodies (Company C) at dilution of 1:1000, 1:10000 and 1:200000. 3. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with IL4 using Phospho-Stat6 (Tyr641) Antibody, Rabbit MAb at 1:10000 dilution. (Validation Experiment) 4. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with IL4 or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-Stat6 (Tyr641) Antibody, Rabbit MAb at 1:10000 dilution. (Validation Experiment) |
| Application | WB |
| Recommended Dose | WB: 1:2000-1:20000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Tyr641 of the Human Stat6. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: residues around Tyr641 of the Human Stat6 |
| Antigen Species | Human |
| Biology Area | Apoptosis Transcription Factors and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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