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PS210

Name: PS210
Brand: TargetMol
SKU: T16670
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16670Cas No. 1221962-86-2

PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.

PS210

🥰Excellent

Purity: 99.78%

Catalog No. T16670Cas No. 1221962-86-2

Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$44	In Stock
5 mg	$68	In Stock
10 mg	$109	In Stock
25 mg	$207	In Stock
50 mg	$369	In Stock
100 mg	$549	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock

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Batch Information

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Purity:99.78%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.
Targets&IC50	PDK1:(kd)3 μM
In vitro	PS210 stabilized the residue Arg131 when PS210 causes stabilization of PDK1 to the temperature gradient, located opposite to the helix a-B at the other extreme of the helix a-C. So, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation[1].

Chemical Properties

Molecular Weight	380.31
Formula	C₁₉H₁₅F₃O₅
Cas No.	1221962-86-2
Smiles	OC(=O)C(C(CC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(O)=O
Relative Density.	1.400 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (157.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6294 mL	13.1472 mL	26.2943 mL	131.4717 mL
5 mM	0.5259 mL	2.6294 mL	5.2589 mL	26.2943 mL
10 mM	0.2629 mL	1.3147 mL	2.6294 mL	13.1472 mL
20 mM	0.1315 mL	0.6574 mL	1.3147 mL	6.5736 mL
50 mM	0.0526 mL	0.2629 mL	0.5259 mL	2.6294 mL
100 mM	0.0263 mL	0.1315 mL	0.2629 mL	1.3147 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc