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CaMKP Inhibitor

Name: CaMKP Inhibitor
Brand: TargetMol
SKU: T2159
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2159Cas No. 52789-62-5

CaMKP Inhibitor can inhibit CaMKP.

CaMKP Inhibitor

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Purity: 99.98%

Catalog No. T2159Cas No. 52789-62-5

CaMKP Inhibitor can inhibit CaMKP.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$371	In Stock	In Stock
100 mg	$512	In Stock	In Stock
500 mg	$1,150	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA

Product Introduction

Bioactivity

Description

CaMKP Inhibitor can inhibit CaMKP.

Kinase Assay

Biacore study: Competition assay is performed on a Biacore S51. A Series S Sensor chip CM5 is utilized for the immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~200 response units (1 response unit corresponds to 1 pg of protein per mm 2). The concentration of MDM2 protein is kept constant at 300 nM. Nutlin-3 is dissolved in DMSO at 10 mM and further diluted to make a concentration series of Nutlin-3 in each MDM2 test sample. The assay is run at 25°C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of Nutlin-3 is calculated as a percentage of binding in the absence of Nutlin-3 and IC50 is calculated

Chemical Properties

Molecular Weight	341.28
Formula	C₁₀H₈NNaO₇S₂
Cas No.	52789-62-5
Smiles	[Na+].Nc1c(cc(c2c1c(O)ccc2)S(=O)(=O)[O-])S(=O)(=O)O
Relative Density.	1.477 g/mL at 25 °C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 34.48 mg/mL (101.03 mM), Sonication is recommended.

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9301 mL	14.6507 mL	29.3015 mL	146.5073 mL
5 mM	0.5860 mL	2.9301 mL	5.8603 mL	29.3015 mL
10 mM	0.2930 mL	1.4651 mL	2.9301 mL	14.6507 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1465 mL	0.7325 mL	1.4651 mL	7.3254 mL
50 mM	0.0586 mL	0.2930 mL	0.5860 mL	2.9301 mL
100 mM	0.0293 mL	0.1465 mL	0.2930 mL	1.4651 mL

Calculator

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Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc