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Tecadenoson

Name: Tecadenoson
Brand: TargetMol
SKU: T17023
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17023Cas No. 204512-90-3

Alias CVT-510

Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist.

Tecadenoson

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Purity: 98.83%

Catalog No. T17023Alias CVT-510Cas No. 204512-90-3

Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$188	In Stock	In Stock
25 mg	$323	In Stock	In Stock
50 mg	$457	In Stock	In Stock
100 mg	$592	In Stock	In Stock
200 mg	$783	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$130	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.83%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist.
In vitro	Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41?nM) than to increase coronary conductance (EC50=200?nM) in the atrial-paced isolated heart. Tecadenoson shortens atrial (EC50=73?nM) but not the ventricular monophasic action potentials (MAP). At concentrations of Tecadenoson (40?nM) and diltiazem (1?μM) that induces equal prolongation of S-H interval (～10?ms), diltiazem, but not Tecadenoson, significantly decreases left ventricular developed pressure (LVP) and markedly increases coronary conductance [1].
In vivo	Intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval In atrial-paced anaesthetized guinea-pigs. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson (50 μg/kg) treatment induces a significant bradycardia (50% decrease in heart rate at 25 min) [1][2].
Synonyms	CVT-510

Chemical Properties

Molecular Weight	337.33
Formula	C₁₄H₁₉N₅O₅
Cas No.	204512-90-3
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@@H]3CCOC3)ncnc12
Relative Density.	1.89g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 155 mg/mL (459.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9645 mL	14.8223 mL	29.6446 mL	148.2228 mL
5 mM	0.5929 mL	2.9645 mL	5.9289 mL	29.6446 mL
10 mM	0.2964 mL	1.4822 mL	2.9645 mL	14.8223 mL
20 mM	0.1482 mL	0.7411 mL	1.4822 mL	7.4111 mL
50 mM	0.0593 mL	0.2964 mL	0.5929 mL	2.9645 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc