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MS023 trihydrochloride
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Catalog No. T77787Cas No. 2108631-19-0
Alias MS023 3HCl
MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.
MS023 trihydrochloride
Copy Product Info😃Good
Catalog No. T77787Alias MS023 3HClCas No. 2108631-19-0
MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | 35 days | 35 days | |
| 5 mg | $885 | 35 days | 35 days | |
| 10 mg | $1,580 | 35 days | 35 days | |
| 25 mg | $3,460 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research. |
| Targets&IC50 | PRMT8:5 nM, PRMT1:30 nM, PRMT4:83 nM, PRMT3:119 nM, PRMT6:4 nM |
| In vitro | MS023 trihydrochloride (1-1000 nM; 48 hours) inhibits the activity of PRMT1 methyltransferase in MCF7 cells[2]. MS023 trihydrochloride (1-1000 nM; 20 hours) inhibits the activity of PRMT6 methyltransferase in HEK293 cells[2].' |
| In vivo | Combination administration of MS023 trihydrochloride (160 mg/kg, ip) and PKC412 (100 mg/kg, ig) disrupts the propagation of MLL-r Acute Lymphoblastic Leukemia (ALL) by inhibiting the maintenance of functional MLL-r ALL initiating cells[1]. |
| Synonyms | MS023 3HCl |
| Molecular Weight | 396.78 |
| Formula | C17H28Cl3N3O |
| Cas No. | 2108631-19-0 |
| Smiles | CN(CCN)CC1=CNC=C1C2=CC=C(C=C2)OC(C)C.Cl.Cl.Cl |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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