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MS023 trihydrochloride

Catalog No. T77787 CAS 2108631-19-0

Synonyms: MS023 3HCl

MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.

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MS023 trihydrochloride Chemical Structure

MS023 trihydrochloride, CAS 2108631-19-0

Pack Size	Availability	Price/USD
1 mg	35 days	$ 143.00
5 mg	35 days	$ 623.00
10 mg	35 days	$ 1,090.00
25 mg	35 days	$ 2,390.00

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Purity: 99.81%

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Description	MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.
Targets&IC50	PRMT6:4 nM, PRMT8:5 nM, PRMT4:83 nM, PRMT3:119 nM, PRMT1:30 nM
In vitro	MS023 trihydrochloride (1-1000 nM; 48 hours) inhibits the activity of PRMT1 methyltransferase in MCF7 cells[2]. MS023 trihydrochloride (1-1000 nM; 20 hours) inhibits the activity of PRMT6 methyltransferase in HEK293 cells[2].'
In vivo	Combination administration of MS023 trihydrochloride (160 mg/kg, ip) and PKC412 (100 mg/kg, ig) disrupts the propagation of MLL-r Acute Lymphoblastic Leukemia (ALL) by inhibiting the maintenance of functional MLL-r ALL initiating cells[1].

Synonyms	MS023 3HCl
Molecular Weight	396.78
Formula	C17H28Cl3N3O
CAS No.	2108631-19-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268. 2. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.

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PRMT4-IN-3 Antitumor agent-101 UNC1999 UNC 0631 Antiproliferative agent-25 UNC7096 MS8511 HCl MS9715

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MS023 trihydrochloride 2108631-19-0 Chromatin/Epigenetic Histone Methyltransferase MS023 3HCl inhibitor inhibit

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