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Anti-JAML Antibody (9J344)
😃Good
Catalog No. TMAY-00300
Alias Gm638, Crea7, AMICA, adhesion molecule, interacts with CXADR antigen 1
Anti-JAML Antibody (9J344) is a Mouse antibody targeting JAML. Anti-JAML Antibody (9J344) can be used in ELISA.
Anti-JAML Antibody (9J344)
Anti-JAML Antibody (9J344)
😃Good
Catalog No. TMAY-00300Alias Gm638, Crea7, AMICA, adhesion molecule, interacts with CXADR antigen 1
Anti-JAML Antibody (9J344) is a Mouse antibody targeting JAML. Anti-JAML Antibody (9J344) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-JAML Antibody (9J344) is a Mouse antibody targeting JAML. Anti-JAML Antibody (9J344) can be used in ELISA. |
| Alias | Gm638, Crea7, AMICA, adhesion molecule, interacts with CXADR antigen 1 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 9J344 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAML / AMICA1 (rh JAML / AMICA1; TMPY-01164; NP_001091996.1; Met1-Leu275). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human JAML / AMICA1 protein (TMPY-01164) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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