Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 313.00 | |
100 mg | In stock | $ 493.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM). |
In vitro | CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons[1]. |
In vivo | In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT[1]. |
Synonyms | GPR52 antagonist-1 |
Molecular Weight | 242.34 |
Formula | C15H14OS |
CAS No. | 1239987-91-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: 10 mg/mL
DMSO: 245 mg/mL (1010.98 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CAY10786 1239987-91-7 Endocrinology/Hormones GPCR/G Protein GPR Inhibitor Huntington’s disease inhibit HdhQ140 GPR52 antagonist-1 CAY 10786 CAY-10786 inhibitor