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CAY10786

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Catalog No. T36036Cas No. 1239987-91-7
Alias GPR52 antagonist-1

CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).

CAY10786

CAY10786

🥰Excellent
Purity: 99.82%
Catalog No. T36036Alias GPR52 antagonist-1Cas No. 1239987-91-7
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$32In StockIn Stock
5 mg$50In StockIn Stock
10 mg$80In StockIn Stock
25 mg$177In StockIn Stock
50 mg$282In StockIn Stock
100 mg$453In StockIn Stock
200 mg$655-In Stock
1 mL x 10 mM (in DMSO)$55In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.82%
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Product Introduction

Bioactivity
Description
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
In vitro
CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons[1].
In vivo
In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT[1].
SynonymsGPR52 antagonist-1
Chemical Properties
Molecular Weight242.34
FormulaC15H14OS
Cas No.1239987-91-7
SmilesO=C(\C=C\CCc1ccccc1)c1cccs1
Relative Density.1.130 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Chloroform: 10 mg/mL (41.26 mM), Sonication is recommended.
DMSO: 245 mg/mL (1010.98 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (20.63 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Chloroform/DMSO
1mg5mg10mg50mg
1 mM4.1264 mL20.6322 mL41.2643 mL206.3217 mL
5 mM0.8253 mL4.1264 mL8.2529 mL41.2643 mL
10 mM0.4126 mL2.0632 mL4.1264 mL20.6322 mL
20 mM0.2063 mL1.0316 mL2.0632 mL10.3161 mL
DMSO
1mg5mg10mg50mg
50 mM0.0825 mL0.4126 mL0.8253 mL4.1264 mL
100 mM0.0413 mL0.2063 mL0.4126 mL2.0632 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHuntington's diseaseHdhQ140GPR52CAY-10786CAY10786CAY 10786
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