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PD 174265

Name: PD 174265
Brand: TargetMol
SKU: T28339
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28339Cas No. 216163-53-0

Alias PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.

PD 174265

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Purity: 99.51%

Catalog No. T28339Alias PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamideCas No. 216163-53-0

PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$38	In Stock	In Stock
25 mg	$57	In Stock	In Stock
50 mg	$80	In Stock	In Stock
100 mg	$116	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

PD 174265 AI Summary

PD 174265 is a multi-target kinase inhibitor with varied bioactivities. It effectively inhibits the EphB2 receptor tyrosine kinase, as demonstrated in an ELISA assay with an IC50 value of 180,000 nM. The compound shows potent inhibition of the EGFR with an IC50 of 0.43 nM and retains activity against the drug-resistant EGFR-T790M mutant with an IC50 of 360 nM. Against chicken cSrc, PD 174265 has an IC50 of 6,400 nM for the single mutant and exhibits significantly reduced potency with an IC50 greater than 50,000 nM for the drug-resistant double mutant. Moreover, PD 174265 demonstrates notable bioactivity in growth inhibition assays: it inhibits the growth of human A431 cells with a GI50 of 21.0 nM after 72 hours, induces cell cycle arrest, and triggers apoptosis in these cells. Specifically, it arrests 60.0% of cells in the G1 phase, 12.3% in the G2/M phase, and 27.7% in the S phase at 1 µM concentration after 24 hours, and induces early apoptotic cells (18.0%) and late apoptotic/necrotic cells (3.9%) after 12 hours at the same concentration. The compound also shows inhibitory effects on wild type and mutant EGFR with varying GI50 values in mouse BA/F3 cells expressing different EGFR mutations, demonstrating lower GI50 values (< 500.0 nM) for cells with certain mutations and higher values (> 5000.0 nM) for others, highlighting its potential application as a targeted therapeutic in EGFR-related conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.
Synonyms	PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

Chemical Properties

Molecular Weight	371.23
Formula	C₁₇H₁₅BrN₄O
Cas No.	216163-53-0
Smiles	CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (26.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6937 mL	13.4687 mL	26.9375 mL	134.6874 mL
5 mM	0.5387 mL	2.6937 mL	5.3875 mL	26.9375 mL
10 mM	0.2694 mL	1.3469 mL	2.6937 mL	13.4687 mL
20 mM	0.1347 mL	0.6734 mL	1.3469 mL	6.7344 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc