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ELB-139
🥰Excellent
Catalog No. T27252Cas No. 188116-08-7
Alias ELB139, ELB 139
ELB-139 is a GABAA receptor agonist that can be used to study depression and epilepsy.
ELB-139
🥰Excellent
Catalog No. T27252Alias ELB139, ELB 139Cas No. 188116-08-7
ELB-139 is a GABAA receptor agonist that can be used to study depression and epilepsy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 2 mg | $436 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:>99.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | ELB-139 is a GABAA receptor agonist that can be used to study depression and epilepsy. |
| In vitro | The IC(50) for the binding site of ELB139 to flunitrazepam in rat forebrain cortical membranes was 1390 nM.In rat hippocampal neurons, ELB139 potentiated GABA-induced currents without maximal effects of diazepam, suggesting partial benzodiazepine agonism. [5] |
| In vivo | ELB139 (10 and 30 mg/kg orally) was active in three different animal models of anxiety in elevated plus maze, light and dark boxes, and Vogel conflict tests. [5] |
| Synonyms | ELB139, ELB 139 |
| Molecular Weight | 277.75 |
| Formula | C14H16ClN3O |
| Cas No. | 188116-08-7 |
| Smiles | O=C1N=C(N2CCCCC2)CN1C3=CC=C(Cl)C=C3 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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