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Pregnanolone sulfate (pyridinium)

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Catalog No. T81409Cas No. 124107-39-7
Alias Pregnanolone sulfate pyridinium

Pregnanolone sulfate (pyridinium) is an endogenous neurosteroid that acts as an inhibitor of NMDA receptors, which reduces excitatory glutamatergic neurotransmission and conferring neuroprotective effects, and is frequently used in neuroscience research to study synaptic modulation, excitotoxicity, neurodegeneration, and the regulatory roles of neurosteroids in central nervous system disorders.

Pregnanolone sulfate (pyridinium)

Pregnanolone sulfate (pyridinium)

Copy Product Info
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Catalog No. T81409Alias Pregnanolone sulfate pyridiniumCas No. 124107-39-7
Pregnanolone sulfate (pyridinium) is an endogenous neurosteroid that acts as an inhibitor of NMDA receptors, which reduces excitatory glutamatergic neurotransmission and conferring neuroprotective effects, and is frequently used in neuroscience research to study synaptic modulation, excitotoxicity, neurodegeneration, and the regulatory roles of neurosteroids in central nervous system disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mgInquiry8-10 weeks8-10 weeks
50 mgInquiry8-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Pregnanolone sulfate (pyridinium) is an endogenous neurosteroid that acts as an inhibitor of NMDA receptors, which reduces excitatory glutamatergic neurotransmission and conferring neuroprotective effects, and is frequently used in neuroscience research to study synaptic modulation, excitotoxicity, neurodegeneration, and the regulatory roles of neurosteroids in central nervous system disorders.
SynonymsPregnanolone sulfate pyridinium
Chemical Properties
Molecular Weight477.66
FormulaC26H39NO5S
Cas No.124107-39-7
SmilesC=1C=CN=CC1.C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC[C@@]1(C[C@H](OS(=O)(=O)O)CC2)[H])[H])[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (167.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0935 mL10.4677 mL20.9354 mL104.6770 mL
5 mM0.4187 mL2.0935 mL4.1871 mL20.9354 mL
10 mM0.2094 mL1.0468 mL2.0935 mL10.4677 mL
20 mM0.1047 mL0.5234 mL1.0468 mL5.2338 mL
50 mM0.0419 mL0.2094 mL0.4187 mL2.0935 mL
100 mM0.0209 mL0.1047 mL0.2094 mL1.0468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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