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Pregnanolone sulfate (pyridinium)

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Catalog No. T81409Cas No. 124107-39-7
Alias Pregnanolone sulfate pyridinium

Pregnanolone sulfate (pyridinium) is an endogenous neurosteroid that acts as an inhibitor of NMDA receptors, which reduces excitatory glutamatergic neurotransmission and conferring neuroprotective effects, and is frequently used in neuroscience research to study synaptic modulation, excitotoxicity, neurodegeneration, and the regulatory roles of neurosteroids in central nervous system disorders.

Pregnanolone sulfate (pyridinium)

Pregnanolone sulfate (pyridinium)

😃Good
Catalog No. T81409Alias Pregnanolone sulfate pyridiniumCas No. 124107-39-7
Pregnanolone sulfate (pyridinium) is an endogenous neurosteroid that acts as an inhibitor of NMDA receptors, which reduces excitatory glutamatergic neurotransmission and conferring neuroprotective effects, and is frequently used in neuroscience research to study synaptic modulation, excitotoxicity, neurodegeneration, and the regulatory roles of neurosteroids in central nervous system disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mgInquiry8-10 weeks8-10 weeks
50 mgInquiry8-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Pregnanolone sulfate (pyridinium) is an endogenous neurosteroid that acts as an inhibitor of NMDA receptors, which reduces excitatory glutamatergic neurotransmission and conferring neuroprotective effects, and is frequently used in neuroscience research to study synaptic modulation, excitotoxicity, neurodegeneration, and the regulatory roles of neurosteroids in central nervous system disorders.
SynonymsPregnanolone sulfate pyridinium
Chemical Properties
Molecular Weight477.66
FormulaC26H39NO5S
Cas No.124107-39-7
SmilesC=1C=CN=CC1.C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC[C@@]1(C[C@H](OS(=O)(=O)O)CC2)[H])[H])[H]
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (167.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0935 mL10.4677 mL20.9354 mL104.6770 mL
5 mM0.4187 mL2.0935 mL4.1871 mL20.9354 mL
10 mM0.2094 mL1.0468 mL2.0935 mL10.4677 mL
20 mM0.1047 mL0.5234 mL1.0468 mL5.2338 mL
50 mM0.0419 mL0.2094 mL0.4187 mL2.0935 mL
100 mM0.0209 mL0.1047 mL0.2094 mL1.0468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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