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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $45 | In Stock | |
1 g | $59 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic. Rifampicin has a strong antibacterial effect against Mycobacterium tuberculosis and is also effective against gram-positive and gram-negative bacteria and viruses. |
In vitro | METHODS: PC12 cells were treated with Rifampicin (25-100 µM) for 3-24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: At 6 h of incubation, Rifampicin induced a significant increase in GRP78 protein expression in PC12 cells. Prolonged incubation with Rifampicin further enhanced the induction of GRP78 up to 24 h. PC12 cells showed a dose-dependent induction of GRP78 when incubated with Rifampicin at concentrations in the 25-100 µM range. [1] METHODS: Human colon cancer cells LS180 were treated with Rifampicin (10 µM) for 24-144 h. Gene levels were measured by RT-PCR. RESULTS: The total expression of NR1I2 mRNA was reduced by 40% after 24 h of Rifampicin treatment, and the expression of PXR.3 mRNA was reduced by 45% after 24 h of Rifampicin treatment. [2] |
In vivo | Rifampicin (200, 400 mg/kg) can induce fatty liver at high concentrations [4]. Rifampicin (30 mg/kg, i.p.) treatment of S464P biofilms in vivo causes a slight decline in bioluminescence from these catheters compared with the parental signal, but it does not affect bioluminescence in mice infected with mutant H481Y [5]. |
Alias | Rifamycin AMP, Rimactane, Rifampin |
Molecular Weight | 822.94 |
Formula | C43H58N4O12 |
Cas No. | 13292-46-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (60.76 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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