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Eriodictyol

Name: Eriodictyol
Brand: TargetMol
SKU: T6S0232
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S0232Cas No. 552-58-9

Alias Huazhongilexone

1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3. Eriodictyol may be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness inAtopic dermatitis.

Eriodictyol

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Purity: 99.32%

Catalog No. T6S0232Alias HuazhongilexoneCas No. 552-58-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$84	In Stock	In Stock
25 mg	$138	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$289	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Eriodictyol AI Summary

Eriodictyol is a multifaceted bioactive molecule exhibiting various inhibitory activities. In primary cultured mouse hepatocytes, it inhibits D-Gal-induced cytotoxicity with increasing efficacy at higher concentrations. It shows antiproliferative activity against U937 cells (IC50 > 100,000 nM) but is weak or non-effective within the tested time frames. The compound inhibits cow milk xanthine oxidase at 50 µg/mL with a 47.8% inhibition rate and demonstrates chemopreventive activity in Syrian hamster embryo cells by inhibiting benzo(a)pyrene metabolism. It protects mouse L929 cells against TNF-alpha-induced cytotoxicity with EC50 values of 4000 nM and 6000 nM using crystal violet and [methyl-3H]thymidine assays, respectively. Eriodictyol shows moderate to high cytotoxicity against various human cell lines, an ED50 greater than 1.0 x 10^3 nM, and induces quinone reductase activity at concentrations greater than 10 µg/mL. Moreover, Eriodictyol exhibits antimicrobial efficacy against Helicobacter pylori (MIC = 50 µg/mL) and binds to and inhibits xanthine oxidase. It also modulates human HEK293 cell EGR1 mRNA expression and possesses antileishmanial activity against Leishmania donovani and Leishmania mexicana, as well as antitrypanosomal activity. It binds to Enterococcus faecalis KAS3 and inhibits both regular and vancomycin-resistant strains (MICs of 256 µg/mL and 512 µg/mL, respectively). It demonstrates inhibitory action against Clostridium welchii neuraminidase (IC50 = 15,970 nM) and theophylline-stimulated melanogenesis in B16-4A5 cells with an IC50 of 32,000 nM. It has antioxidant properties via TEAC assay (1.8 MU) and enzyme inhibition of CYP1B1, CYP1A1, and CYP1A2. It protects against doxorubicin-induced cytotoxicity in rat H9c2 cells and influences adipogenesis in mouse 3T3L1 cells. Additionally, the compound inhibits both erythrocyte Acetylcholinesterase (IC50 = 1,663,800 nM) and equine Butyrylcholinesterase (IC50 = 1,124,400 nM), and shows mixed bioactivity in human AChE and BChE isoforms. Eriodictyol demonstrates weak inhibition of human SET7 (IC50 > 200,000 nM), human liver FBP1, and moderate inhibition of OATP2B1 uptake (IC50 ≈ 28,700 nM). The compound also inhibits quorum sensing in Pseudomonas aeruginosa, elastic production, Influenza A virus polymerase acidic subunit, and human OATP2B1-substrate interactions, while activating Nrf2 in Hepa1c1c7 cells and having significant anti-inflammatory and osteogenic differentiation capacities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3. Eriodictyol may be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness inAtopic dermatitis.
Synonyms	Huazhongilexone

Chemical Properties

Molecular Weight	288.25
Formula	C₁₅H₁₂O₆
Cas No.	552-58-9
Smiles	Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1
Relative Density.	1.586 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (849.96 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4692 mL	17.3461 mL	34.6921 mL	173.4605 mL
5 mM	0.6938 mL	3.4692 mL	6.9384 mL	34.6921 mL
10 mM	0.3469 mL	1.7346 mL	3.4692 mL	17.3461 mL
20 mM	0.1735 mL	0.8673 mL	1.7346 mL	8.6730 mL
50 mM	0.0694 mL	0.3469 mL	0.6938 mL	3.4692 mL
100 mM	0.0347 mL	0.1735 mL	0.3469 mL	1.7346 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc