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(S,S)-GNE 5729

Name: (S,S)-GNE 5729
Brand: TargetMol
SKU: T15408L
Rating: 4.5 (1 reviews)

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Catalog No. T15408LCas No. 2026636-06-4

Alias (S,S)-GNE5729

(S,S)-GNE 5729 is an enantiomer of GNE 5729, widely used in biochemical experiments and drug synthesis research. GNE 5729 is a blood-brain barrier-permeable positive modulator of the NMDAR.

(S,S)-GNE 5729

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Purity: 99.48%

Catalog No. T15408LAlias (S,S)-GNE5729Cas No. 2026636-06-4

(S,S)-GNE 5729 is an enantiomer of GNE 5729, widely used in biochemical experiments and drug synthesis research. GNE 5729 is a blood-brain barrier-permeable positive modulator of the NMDAR.

Product information is being updated, if you want to purchase, please click the bulk custom button.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

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Batch Information

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Purity:99.48%

ee:100%

Appearance:Solid

Color:Yellow

Resource Download

COA CNMR CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	(S,S)-GNE 5729 is an enantiomer of GNE 5729, widely used in biochemical experiments and drug synthesis research. GNE 5729 is a blood-brain barrier-permeable positive modulator of the NMDAR.
Synonyms	(S,S)-GNE5729

Chemical Properties

Molecular Weight	428.2
Formula	C₁₇H₁₀Cl₂F₃N₅O
Cas No.	2026636-06-4
Smiles	ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@@H]4[C@@H](C#N)C4
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (186.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3354 mL	11.6768 mL	23.3536 mL	116.7679 mL
5 mM	0.4671 mL	2.3354 mL	4.6707 mL	23.3536 mL
10 mM	0.2335 mL	1.1677 mL	2.3354 mL	11.6768 mL
20 mM	0.1168 mL	0.5838 mL	1.1677 mL	5.8384 mL
50 mM	0.0467 mL	0.2335 mL	0.4671 mL	2.3354 mL
100 mM	0.0234 mL	0.1168 mL	0.2335 mL	1.1677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc