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(S,S)-GNE 5729

Name: (S,S)-GNE 5729
Brand: TargetMol
SKU: T15408L
Rating: 4.5 (1 reviews)

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Catalog No. T15408LCas No. 2026636-06-4

Alias (S,S)-GNE5729

(S,S)-GNE 5729 is an enantiomer of GNE 5729, widely used in biochemical experiments and drug synthesis research. GNE 5729 is a blood-brain barrier-permeable positive modulator of the NMDAR.

(S,S)-GNE 5729

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Purity: 99.48%

Catalog No. T15408LAlias (S,S)-GNE5729Cas No. 2026636-06-4

(S,S)-GNE 5729 is an enantiomer of GNE 5729, widely used in biochemical experiments and drug synthesis research. GNE 5729 is a blood-brain barrier-permeable positive modulator of the NMDAR.

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Batch Information

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Purity:99.48%

ee:100%

Resource Download

COA CNMR CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	(S,S)-GNE 5729 is an enantiomer of GNE 5729, widely used in biochemical experiments and drug synthesis research. GNE 5729 is a blood-brain barrier-permeable positive modulator of the NMDAR.
Synonyms	(S,S)-GNE5729

Chemical Properties

Molecular Weight	428.2
Formula	C₁₇H₁₀Cl₂F₃N₅O
Cas No.	2026636-06-4
Smiles	ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@@H]4[C@@H](C#N)C4
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (186.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3354 mL	11.6768 mL	23.3536 mL	116.7679 mL
5 mM	0.4671 mL	2.3354 mL	4.6707 mL	23.3536 mL
10 mM	0.2335 mL	1.1677 mL	2.3354 mL	11.6768 mL
20 mM	0.1168 mL	0.5838 mL	1.1677 mL	5.8384 mL
50 mM	0.0467 mL	0.2335 mL	0.4671 mL	2.3354 mL
100 mM	0.0234 mL	0.1168 mL	0.2335 mL	1.1677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc