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Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody
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Catalog No. TMAB-10531
Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cofilin (Tyr89). Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody
Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-10531
Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cofilin (Tyr89). Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Antigen Details
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| Description | Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cofilin (Tyr89). Anti-Phospho-Cofilin (Tyr89) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (Human brain glioblastoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-Cofilin (Tyr89)) Polyclonal Antibody, Unconjugated (TMAB-10531) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. |
| Tissue Specificity | Widely distributed in various tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human Cofilin around the phosphorylation site of Tyr89 |
| Antigen Species | Human |
| Gene Name | CFL1 |
| Gene ID | |
| Protein Name | Cofilin-1 |
| Uniprot ID | |
| Function | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
| Molecular Weight | Theoretical: 18 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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