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DUB-IN-1

🥰Excellent
Catalog No. T11110Cas No. 924296-18-4

DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).

DUB-IN-1

DUB-IN-1

🥰Excellent
Purity: 98.96%
Catalog No. T11110Cas No. 924296-18-4
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$59In StockIn Stock
5 mg$118In StockIn Stock
10 mg$193In StockIn Stock
25 mg$371In StockIn Stock
50 mg$521In StockIn Stock
100 mg$687In StockIn Stock
200 mg$943In StockIn Stock
1 mL x 10 mM (in DMSO)$130In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.96%
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COA HPLC

Product Introduction

Bioactivity
Description
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
Targets&IC50
USP8:0.24 μM
In vitro
DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM.DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8.
Chemical Properties
Molecular Weight337.33
FormulaC20H11N5O
Cas No.924296-18-4
SmilesN#Cc1nc2\C(=N\OCc3ccccc3)c3ccccc3-c2nc1C#N
Relative Density.1.32g/cm3
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (133.4 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (5.93 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9645 mL14.8223 mL29.6446 mL148.2228 mL
5 mM0.5929 mL2.9645 mL5.9289 mL29.6446 mL
10 mM0.2964 mL1.4822 mL2.9645 mL14.8223 mL
20 mM0.1482 mL0.7411 mL1.4822 mL7.4111 mL
50 mM0.0593 mL0.2964 mL0.5929 mL2.9645 mL
100 mM0.0296 mL0.1482 mL0.2964 mL1.4822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

USP8InhibitorinhibitDUBsDUB-IN-1DUBIN1DUB IN 1Deubiquitinase
Related Tags: buy DUB-IN-1 | purchase DUB-IN-1 | DUB-IN-1 cost | order DUB-IN-1 | DUB-IN-1 chemical structure | DUB-IN-1 in vitro | DUB-IN-1 formula | DUB-IN-1 molecular weight
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