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TDI-11055

Name: TDI-11055
Brand: TargetMol
SKU: T87946
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T87946

Alias TDI11055, TDI 11055

TDI-11055 is an orally available inhibitor of chromatin reader 11-19 leukemia (ENL) that works by blocking the interaction of its YEATS domain with acylated histones. TDI-11055 can be used to study acute myeloid leukemia (AML).

TDI-11055

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Purity: 98.48%

Catalog No. T87946Alias TDI11055, TDI 11055

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$795	-	In Stock
50 mg	$1,220	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.48%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TDI-11055 is an orally available inhibitor of chromatin reader 11-19 leukemia (ENL) that works by blocking the interaction of its YEATS domain with acylated histones. TDI-11055 can be used to study acute myeloid leukemia (AML).
Targets&IC50	AF9 YEATS domain:0.07 μmol/L, ENL YEATS domain:0.05 μmol/L
In vitro	Time-resolved fluorescence energy transfer (TR-FRET) assays were used to measure the inhibitory effects of TDI-11055 on the interactions between different YEATS domains and acylated histone peptides. TDI-11055 retained potency and selectivity for the YEATS domains of ENL (IC50 = 0.05 μmol/L) and AF9 (IC50 = 0.07 μmol/L) but showed no inhibition of the YEATS domains of GAS41 and YEATS2. [2]
In vivo	Mouse xenograft model using MV4;11 cells subcutaneously implanted into BALB/c nude mice. After tumors reached approximately 300 to 400 mm3, treatment with TDI-11055 [100 or 200 mg/kg, per os (p.o.), b.i.d.] or vehicle was initiated and continued for 8 consecutive days. Dosing with TDI-11055 twice daily resulted in significant inhibition of tumor growth over 8 days of treatment with no overt effect on body weight. Gene expression analysis of tumors at the end of treatment revealed a substantial reduction in the expression of key ENL target genes (HOXA9, MYC, MEIS1, and MYB) in tumors in the TDI-11055–-treated group compared with vehicle controls. [2]
Synonyms	TDI11055, TDI 11055

Chemical Properties

Molecular Weight	388.47
Formula	C₂₂H₂₄N₆O
Smiles	C[C@@H](CCC1)N1CC2=CC3=C(N2)C=C(NC(C4=CC(C=NN5C)=C5C=C4)=O)N=C3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (205.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.49 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5742 mL	12.8710 mL	25.7420 mL	128.7101 mL
5 mM	0.5148 mL	2.5742 mL	5.1484 mL	25.7420 mL
10 mM	0.2574 mL	1.2871 mL	2.5742 mL	12.8710 mL
20 mM	0.1287 mL	0.6436 mL	1.2871 mL	6.4355 mL
50 mM	0.0515 mL	0.2574 mL	0.5148 mL	2.5742 mL
100 mM	0.0257 mL	0.1287 mL	0.2574 mL	1.2871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc