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Anti-TMEFF1/Tomoregulin-1 Antibody
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Catalog No. T9901A-1387 Copy Product Info
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Anti-TMEFF1/Tomoregulin-1 Antibody is a functional monoclonal antibody specifically targeting Tomoregulin-1 (TMEFF1/HPP1), a type-I transmembrane protein. TMEFF1 features two Follistatin modules and an EGF-like domain, playing significant roles in embryonic development and tumorigenesis. This antibody specifically recognizes the extracellular Follistatin modules of TMEFF1 and induces programmed cell death (apoptosis) in hematopoietic tumor cell lines (e.g., Jurkat, U937) by activating intracellular signaling pathways. The mechanism of apoptosis induction is unique, involving a rapid rise in intracellular cAMP levels and subsequent activation of Caspase-3. In basic oncology research, this antibody serves as a crucial experimental tool for investigating TMEFF1-mediated cell growth inhibition and apoptotic signaling.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $377 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Antibody Information
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| Description | Anti-TMEFF1/Tomoregulin-1 Antibody is a functional monoclonal antibody specifically targeting Tomoregulin-1 (TMEFF1/HPP1), a type-I transmembrane protein. TMEFF1 features two Follistatin modules and an EGF-like domain, playing significant roles in embryonic development and tumorigenesis. This antibody specifically recognizes the extracellular Follistatin modules of TMEFF1 and induces programmed cell death (apoptosis) in hematopoietic tumor cell lines (e.g., Jurkat, U937) by activating intracellular signaling pathways. The mechanism of apoptosis induction is unique, involving a rapid rise in intracellular cAMP levels and subsequent activation of Caspase-3. In basic oncology research, this antibody serves as a crucial experimental tool for investigating TMEFF1-mediated cell growth inhibition and apoptotic signaling. |
| In vitro | In functional bioassays using hematopoietic cell lines (e.g., L1210, U937, Jurkat), treatment with the Anti-TMEFF1/Tomoregulin-1 Antibody (clone C29 or purified IgG against Follistatin modules) resulted in significant induction of apoptosis, as evidenced by genomic DNA fragmentation, annexin-V positive staining, and caspase-3 activation [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | TMEFF1/Tomoregulin-1 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Anti-TMEFF1/Tomoregulin-1 Antibody chemical structure | Anti-TMEFF1/Tomoregulin-1 Antibody in vitro
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