Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a strong protective effect against glutamate toxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 428.00 | |
50 mg | In stock | $ 639.00 | |
100 mg | In stock | $ 890.00 | |
500 mg | In stock | $ 1,830.00 |
Description | ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a strong protective effect against glutamate toxicity. |
Targets&IC50 | 15-LOX1:3.3 (Ki) |
In vitro | ThioLox (50 μM; 24 h) inhibits the expression of interleukins (IL-1β, IL-6, IL-8, IL-12b, TNFα, and iNOS) in precision-cut lung slices (PCLS). In neuronal cells, ThioLox (10 μM; 16 h) prevents mitochondrial superoxide formation and lipid peroxidation. ThioLox (5-20 μM; 14-16 h) prevents HT-22 cells from glutamate toxicity. ThioLox significantly reduces neuronal cell death[1]. |
In vivo | The logP value of ThioLox is 3, indicating that it is predicted to effectively penetrate the blood-brain barrier[1]. |
Molecular Weight | 274.38 |
Formula | C15H18N2OS |
CAS No. | 1202193-89-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (328.0 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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ThioLox 1202193-89-2 Metabolism Lipoxygenase inhibitor inhibit