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ThioLox

Name: ThioLox
Brand: TargetMol
SKU: T67908
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67908Cas No. 1202193-89-2

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.

ThioLox

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Purity: 99.98%

Catalog No. T67908Cas No. 1202193-89-2

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$48	In Stock
25 mg	$107	In Stock
50 mg	$178	In Stock
100 mg	$311	In Stock
200 mg	$442	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.98%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.
Targets&IC50	15-LOX1:3.3 (Ki)
In vitro	ThioLox (50 μM; 24 h) inhibits the expression of interleukins (IL-1β, IL-6, IL-8, IL-12b, TNFα, and iNOS) in precision-cut lung slices (PCLS). In neuronal cells, ThioLox (10 μM; 16 h) prevents mitochondrial superoxide formation and lipid peroxidation. ThioLox (5-20 μM; 14-16 h) prevents HT-22 cells from glutamate toxicity. ThioLox significantly reduces neuronal cell death[1].
In vivo	The logP value of ThioLox is 3, indicating that it is predicted to effectively penetrate the blood-brain barrier[1].

Chemical Properties

Molecular Weight	274.38
Formula	C₁₅H₁₈N₂OS
Cas No.	1202193-89-2
Smiles	C(NCCCC)(=O)C=1C=C(SC1N)C2=CC=CC=C2
Relative Density.	1.160 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (328.0 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6446 mL	18.2229 mL	36.4458 mL	182.2290 mL
5 mM	0.7289 mL	3.6446 mL	7.2892 mL	36.4458 mL
10 mM	0.3645 mL	1.8223 mL	3.6446 mL	18.2229 mL
20 mM	0.1822 mL	0.9111 mL	1.8223 mL	9.1115 mL
50 mM	0.0729 mL	0.3645 mL	0.7289 mL	3.6446 mL
100 mM	0.0364 mL	0.1822 mL	0.3645 mL	1.8223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc