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ThioLox

Name: ThioLox
Brand: TargetMol
SKU: T67908
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67908Cas No. 1202193-89-2

ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.

ThioLox

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Purity: 99.98%

Catalog No. T67908Cas No. 1202193-89-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$311	In Stock	In Stock
200 mg	$442	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.
Targets&IC50	15-LOX1:3.3 (Ki)
In vitro	ThioLox (50 μM; 24 h) inhibits the expression of interleukins (IL-1β, IL-6, IL-8, IL-12b, TNFα, and iNOS) in precision-cut lung slices (PCLS). In neuronal cells, ThioLox (10 μM; 16 h) prevents mitochondrial superoxide formation and lipid peroxidation. ThioLox (5-20 μM; 14-16 h) prevents HT-22 cells from glutamate toxicity. ThioLox significantly reduces neuronal cell death[1].
In vivo	The logP value of ThioLox is 3, indicating that it is predicted to effectively penetrate the blood-brain barrier[1].

Chemical Properties

Molecular Weight	274.38
Formula	C₁₅H₁₈N₂OS
Cas No.	1202193-89-2
Smiles	C(NCCCC)(=O)C=1C=C(SC1N)C2=CC=CC=C2
Relative Density.	1.160 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (328.01 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6446 mL	18.2229 mL	36.4458 mL	182.2290 mL
5 mM	0.7289 mL	3.6446 mL	7.2892 mL	36.4458 mL
10 mM	0.3645 mL	1.8223 mL	3.6446 mL	18.2229 mL
20 mM	0.1822 mL	0.9111 mL	1.8223 mL	9.1115 mL
50 mM	0.0729 mL	0.3645 mL	0.7289 mL	3.6446 mL
100 mM	0.0364 mL	0.1822 mL	0.3645 mL	1.8223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc