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Golimumab

Catalog No. T76711 CAS 476181-74-5

Synonyms: MK-8259, SCH 900259, CNTO-148

Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-1β, and induces apoptosis.Golimumab can be used to prevent inflammation and destruction of cartilage or bone, and can be used to study rheumatoid arthritis and cancer. Golimumab can be used to prevent inflammation and cartilage or bone destruction and can be used to study rheumatoid arthritis and cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Golimumab, CAS 476181-74-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 297.00
5 mg	In stock	$ 689.00
10 mg	In stock	$ 973.00
25 mg	In stock	$ 1,430.00
50 mg	In stock	$ 1,930.00
100 mg	In stock	$ 2,630.00

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Description	Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-1β, and induces apoptosis.Golimumab can be used to prevent inflammation and destruction of cartilage or bone, and can be used to study rheumatoid arthritis and cancer. Golimumab can be used to prevent inflammation and cartilage or bone destruction and can be used to study rheumatoid arthritis and cancer.
In vitro	Inducing reductions in the viability of transmembrane TNFα–expressing cells, Golimumab (CNTO-148) (0.1-10 μg/mL; 24-72 hours; transmembrane TNFα–transfected Jurkat cells) [1].Inducing apoptosis, increasing the levels of active caspase-3, and inducing apoptotic DNA fragmentation, Golimumab (CNTO-148) (10 μg/mL; 48 hours; transmembrane TNFα–transfected Jurkat cells) [1].
In vivo	Golimumab (CNTO-148), administered intraperitoneally at doses of 1-10 mg/kg daily for 4 weeks in the Tg197 transgenic mouse model, relieves TNFα-induced arthritis in a mouse model of humans [3].Golimumab (CNTO-148), administered intravenously at a dose of 24 mg/kg daily for 7 days in Swiss-albino healthy male mice, inhibits oxidative stress, apoptotic cell death, and inflammatory response, thereby improving renal function. Golimumab reduces all markers of kidney injury and attenuates cell death [3].

Synonyms	MK-8259, SCH 900259, CNTO-148
Molecular Weight	N/A
CAS No.	476181-74-5

Storage

store at low temperature

store at -20°C

References and Literature

1. Ueda N, et, al. The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α. Inflamm Bowel Dis. 2013 May;19(6):1224-31. 2. Shealy DJ, et, al. Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α. MAbs. 2010 Jul-Aug;2(4):428-39. 3. Pavitrakar V, et, al. Amelioration of Cisplatin-induced Renal Inflammation by Recombinant Human Golimumab in Mice. Curr Pharm Biotechnol. 2022;23(7):970-977.

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Keywords

Golimumab 476181-74-5 Apoptosis TNF MK-8259 SCH 900259 CNTO-148 inhibitor inhibit

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