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7-BIA

Name: 7-BIA
Brand: TargetMol
SKU: T10190
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10190Cas No. 1313403-49-4

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties, and is utilized in neuropathic pain research.

7-BIA

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Catalog No. T10190Cas No. 1313403-49-4

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties, and is utilized in neuropathic pain research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$148	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$645	In Stock	In Stock
25 mg	$1,190	In Stock	In Stock
50 mg	$1,880	-	In Stock
100 mg	$2,980	-	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:Yellow

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COA HNMR

Product Introduction

Bioactivity

Description	7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties, and is utilized in neuropathic pain research.
Targets&IC50	PTPRS:40 μM (Human), PTPRD:1-3 μM (Human)
In vitro	7-BIA inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of approximately 1-3 μM and 40 μM, respectively[1].
In vivo	Administered via intraperitoneal injection at a single dose of 10-20 mg/kg, 7-BIA reduces cocaine self-administration in experienced wild-type mice[1].
Animal Research	Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions). Dosage: 10 mg/kg, 20 mg/kg. Administration: Given i.p.; only once

Chemical Properties

Molecular Weight	294.3
Formula	C₁₅H₁₈O₆
Cas No.	1313403-49-4
Smiles	CCCCOc1cc2C(=O)OC(O)Cc2c(C=O)c1OC
Relative Density.	1.279 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (271.83 mM), Sonication is recommended.

Ethanol: 30 mg/mL (101.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3979 mL	16.9895 mL	33.9789 mL	169.8947 mL
5 mM	0.6796 mL	3.3979 mL	6.7958 mL	33.9789 mL
10 mM	0.3398 mL	1.6989 mL	3.3979 mL	16.9895 mL
20 mM	0.1699 mL	0.8495 mL	1.6989 mL	8.4947 mL
50 mM	0.0680 mL	0.3398 mL	0.6796 mL	3.3979 mL
100 mM	0.0340 mL	0.1699 mL	0.3398 mL	1.6989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc