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Alarelin Acetate

Name: Alarelin Acetate
Brand: TargetMol
SKU: T1494
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1494Cas No. 79561-22-1

Alias Alarelin

Alarelin Acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.

Alarelin Acetate

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Purity: 99.81%

Catalog No. T1494Alias AlarelinCas No. 79561-22-1

Alarelin Acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$53	In Stock	In Stock
10 mg	$87	In Stock	In Stock
25 mg	$117	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$189	In Stock	In Stock
500 mg	$475	-	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	Alarelin Acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.
In vitro	Cell viability significantly decreased when exposed to alarelin, as compared to its absence. The peak stimulatory effect on cell viability occurred at a concentration of 10^-5 M, with alarelin demonstrating dose-dependent activity[1].
In vivo	Alarelin effectively suppresses gastric acid secretion in rats through direct interaction with parietal cells and by impairing vagal function [2]. Additionally, Alarelin significantly elevates the ratio of G1 phase while reducing the S phase ratio in rat gastric smooth muscle cells (GSMC) [1].
Cell Research	The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1].
Synonyms	Alarelin

Chemical Properties

Molecular Weight	1167.34
Formula	C₅₆H₇₈N₁₆O₁₂
Cas No.	79561-22-1
Smiles	CC(O)=O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
Relative Density.	1.482 g/cm3
Sequence	H-Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt
Sequence Short	XHWSYALRP

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58 mg/mL (49.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8566 mL	4.2832 mL	8.5665 mL	42.8324 mL
5 mM	0.1713 mL	0.8566 mL	1.7133 mL	8.5665 mL
10 mM	0.0857 mL	0.4283 mL	0.8566 mL	4.2832 mL
20 mM	0.0428 mL	0.2142 mL	0.4283 mL	2.1416 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc