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RIPK1-IN-4

Name: RIPK1-IN-4
Brand: TargetMol
SKU: T12730
Price: 814 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12730 Copy Product Info

Purity: 99.82%

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RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).

RIPK1-IN-4

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Catalog No. T12730

Cas No. 1481641-08-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$121	In Stock	In Stock
5 mg	$243	In Stock	In Stock
10 mg	$343	In Stock	In Stock
25 mg	$600	In Stock	In Stock
50 mg	$814	In Stock	In Stock
100 mg	Inquiry	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.82%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

RIPK1-IN-4 AI Summary

RIPK1-IN-4 shows bioactivity related to the inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) in both human and mouse cells. It demonstrates high binding affinity and potency, with IC50 values of 25.0 nM for mouse RIP1 and 50.0 nM for human RIP1. In functional assays, RIPK1-IN-4 inhibits RIP1 activity in mouse L929 cells with an IC50 of 400.0 nM and in human U937 cells with an IC50 of 500.0 nM. Additionally, it inhibits autophosphorylation of the N-terminal His-GST-TEV-fused RIP1 kinase domain and is effective in displacing a fluorescent ligand from the RIP1 kinase domain. These results suggest that RIPK1-IN-4 may have potential as a RIP1 inhibitor in the context of necroptosis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).
Targets&IC50	RIP1:16 nM , ADP-Glo:10 nM

Chemical Properties

Molecular Weight	401.46
Formula	C₂₃H₂₃N₅O₂
Cas No.	1481641-08-0
Smiles	CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cccc3c(N)nccc23)no1
Relative Density.	1.305 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (560.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4909 mL	12.4545 mL	24.9091 mL	124.5454 mL
5 mM	0.4982 mL	2.4909 mL	4.9818 mL	24.9091 mL
10 mM	0.2491 mL	1.2455 mL	2.4909 mL	12.4545 mL
20 mM	0.1245 mL	0.6227 mL	1.2455 mL	6.2273 mL
50 mM	0.0498 mL	0.2491 mL	0.4982 mL	2.4909 mL
100 mM	0.0249 mL	0.1245 mL	0.2491 mL	1.2455 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc