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Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody
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Catalog No. TMAB-11411
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody
😃Good
Catalog No. TMAB-11411
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Pig,Horse) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Widely expressed in hematopoietic cells but not in other cell types. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human VAV1 around the phosphorylation site of Tyr174 |
| Antigen Species | Human |
| Gene Name | VAV1 |
| Gene ID | |
| Protein Name | Proto-oncogene vav |
| Uniprot ID | |
| Function | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Molecular Weight | Theoretical: 98 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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