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Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody
Catalog No. TMAB-11411 Copy Product Info
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Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-11411
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-VAV1
(Tyr174) Polyclonal Antibody
(Tyr174) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Pig,Horse) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (rat spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with (phospho-VAV1 (Tyr174)) Polyclonal Antibody, Unconjugated (TMAB-11411) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Widely expressed in hematopoietic cells but not in other cell types. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human VAV1 around the phosphorylation site of Tyr174 |
| Antigen Species | Human |
| Gene Name | VAV1 |
| Gene ID | |
| Protein Name | Proto-oncogene vav |
| Uniprot ID | |
| Function | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Molecular Weight | Theoretical: 98 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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