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Pilocarpine Hydrochloride

Name: Pilocarpine Hydrochloride
Brand: TargetMol
SKU: T0804
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0804Cas No. 54-71-7

Alias Pilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochloride

Pilocarpine Hydrochloride (NSC 5746 HCl) is an M3-type muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride was used to make an experimental model of epilepsy.

Pilocarpine Hydrochloride

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Purity: 99.89%

Catalog No. T0804Alias Pilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochlorideCas No. 54-71-7

Pilocarpine Hydrochloride (NSC 5746 HCl) is an M3-type muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride was used to make an experimental model of epilepsy.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock

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Purity:99.89%

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Product Introduction

Bioactivity

Description	Pilocarpine Hydrochloride (NSC 5746 HCl) is an M3-type muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride was used to make an experimental model of epilepsy.
Targets&IC50	CYP2A6 (human liver microsomes):5.31μM, Pentoxyresorufin O-dealkylas (mouse liver microsomes):4 μM, testosterone 6 beta-hydroxylase (mouse liver microsomes):> 1 mM, Astrocytes:31.86 mM, Coumarin 7-hydroxylase (mouse liver microsomes):6 μM, dimethylnitrosamine N-demethylase (human liver microsomes):10 μM, coumarin 7-hydroxylase (human liver microsomes):6 μM, dimethylnitrosamine N-demethylase (mouse liver microsomes):100 μM, Testosterone 15 alpha-hydroxylase (mouse liver microsomes):6 μM
In vivo	METHODS: To study the effect of Pilocarpine Hydrochloride on salivary secretion, Pilocarpine Hydrochloride (0.5 mg/kg) was injected into rats. RESULTS: The salivary secretion volume of exercise group was significantly higher than that of control group (P<0.01). On the contrary, the Na+ concentration in saliva of the exercise group was significantly lower than that of the control group (P<0.05). [1]
Synonyms	Pilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochloride

Chemical Properties

Molecular Weight	244.72
Formula	C₁₁H₁₆N₂O₂·HCl
Cas No.	54-71-7
Smiles	Cl.CCC1C(Cc2cncn2C)COC1=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 24.5 mg/mL (100.11 mM), Sonication is recommended.

DMSO: 138 mg/mL (563.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0863 mL	20.4315 mL	40.8630 mL	204.3151 mL
5 mM	0.8173 mL	4.0863 mL	8.1726 mL	40.8630 mL
10 mM	0.4086 mL	2.0432 mL	4.0863 mL	20.4315 mL
20 mM	0.2043 mL	1.0216 mL	2.0432 mL	10.2158 mL
50 mM	0.0817 mL	0.4086 mL	0.8173 mL	4.0863 mL
100 mM	0.0409 mL	0.2043 mL	0.4086 mL	2.0432 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc