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NT-0527
🥰Excellent
Catalog No. T212606Cas No. 2771019-10-2
Alias NT0527, NT 0527
NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor that inhibits NLRP3-induced IL-1β in human whole blood (IC50 = 0.79 ± 0.4 µM), and can be used for the study of neuroinflammatory diseases.
NT-0527
🥰Excellent
Catalog No. T212606Alias NT0527, NT 0527Cas No. 2771019-10-2
NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor that inhibits NLRP3-induced IL-1β in human whole blood (IC50 = 0.79 ± 0.4 µM), and can be used for the study of neuroinflammatory diseases.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor that inhibits NLRP3-induced IL-1β in human whole blood (IC50 = 0.79 ± 0.4 µM), and can be used for the study of neuroinflammatory diseases. |
| Targets&IC50 | IL-1β:0.79±0.4 μM |
| In vitro | In human whole blood stimulated with LPS and ATP, NT-0527 inhibited NLRP3-induced IL-1β with an IC50 of 0.79 ± 0.4 μM, while having no effect on IL-6 and TNF-α release at concentrations up to 40 μM. [1] |
| Synonyms | NT0527, NT 0527 |
| Molecular Weight | 360.77 |
| Formula | C17H14ClFN4O2 |
| Cas No. | 2771019-10-2 |
| Smiles | O=C1C2=CC=C(Cl)C=C2C3(CN1CC(=O)NC4=NC=C(F)C=N4)CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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