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Dutasteride

Name: Dutasteride
Brand: TargetMol
SKU: T1499
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1499Cas No. 164656-23-9

Alias GI 198745, GG 745, Avodart

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.

Dutasteride

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Purity: 99.58%

Catalog No. T1499Alias GI 198745, GG 745, AvodartCas No. 164656-23-9

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$80	In Stock	In Stock
50 mg	$107	In Stock	In Stock
100 mg	$162	In Stock	In Stock
200 mg	$226	In Stock	In Stock
500 mg	$379	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Color:White

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Product Introduction

Bioactivity

Description	Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
In vitro	In healthy male rats, daily treatment with Dutasteride (100mg/kg) resulted in a prostate size that was half the size of that in control rats.
In vivo	Dutasteride effectively inhibits Type I 5AR (IC50=6 nM) and Type II 5AR (IC50=7 nM). In LNCaP cells (IC50=1 μM), it suppresses DHT-induced PSA secretion and proliferation, and competes for androgen receptor (AR) binding (IC50=1.5 μM). Additionally, dutasteride reduces cell viability and proliferation in both androgen-responsive (LNCaP) and androgen-nonresponsive (DU145) human prostate cancer (PCa) cell lines.
Synonyms	GI 198745, GG 745, Avodart

Chemical Properties

Molecular Weight	528.53
Formula	C₂₇H₃₀F₆N₂O₂
Cas No.	164656-23-9
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H]
Relative Density.	1.303 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 6 mg/mL (11.35 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 44.5 mg/mL (84.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8920 mL	9.4602 mL	18.9204 mL	94.6020 mL
5 mM	0.3784 mL	1.8920 mL	3.7841 mL	18.9204 mL
10 mM	0.1892 mL	0.9460 mL	1.8920 mL	9.4602 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0946 mL	0.4730 mL	0.9460 mL	4.7301 mL
50 mM	0.0378 mL	0.1892 mL	0.3784 mL	1.8920 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc