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MF498

Name: MF498
Brand: TargetMol
SKU: T16069
Rating: 4.5 (1 reviews)

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Catalog No. T16069Cas No. 915191-42-3

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).

MF498

😃Good

Catalog No. T16069Cas No. 915191-42-3

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).

Pack Size	Price	Availability
1 mg	$246	35 days
5 mg	$1,090	35 days
10 mg	$1,920	35 days
25 mg	$4,230	35 days

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Product Introduction

Bioactivity

Description	MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).
Targets&IC50	EP4:0.7 nM (Ki)
In vitro	MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner (IC50: 1.7 and 17 nM in the absence and presence of 10% serum, respectively). MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract.
In vivo	MF498 on inflammation in adjuvant-caused arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA). MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.

Chemical Properties

Molecular Weight	603.69
Formula	C₃₂H₃₃N₃O₇S
Cas No.	915191-42-3
Relative Density.	1.324 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31 mg/mL (51.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6565 mL	8.2824 mL	16.5648 mL	82.8240 mL
5 mM	0.3313 mL	1.6565 mL	3.3130 mL	16.5648 mL
10 mM	0.1656 mL	0.8282 mL	1.6565 mL	8.2824 mL
20 mM	0.0828 mL	0.4141 mL	0.8282 mL	4.1412 mL
50 mM	0.0331 mL	0.1656 mL	0.3313 mL	1.6565 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc