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KT203

Name: KT203
Brand: TargetMol
SKU: T11785
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11785Cas No. 1402612-64-9

KT203, a selective and potent structural domain 6 (ABHD6) inhibitor of alpha/beta hydrolytic enzymes, exhibits potential antiviral and anti-inflammatory properties for pneumonia research.

KT203

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🥰Excellent

Purity: 98.51%

Catalog No. T11785Cas No. 1402612-64-9

KT203, a selective and potent structural domain 6 (ABHD6) inhibitor of alpha/beta hydrolytic enzymes, exhibits potential antiviral and anti-inflammatory properties for pneumonia research.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$56	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$196	In Stock	In Stock
50 mg	$317	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.51%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

KT203 AI Summary

KT203 exhibits potent bioactivity in inhibiting the enzyme ABHD6 across various assays and cell types. The compound demonstrates high inhibitory effects on ABHD6 activity in mouse brain membrane, recombinant mouse DAGLbeta, and mouse Neuro2a cells at different concentrations and time points. The IC50 values indicate strong potency in both in vitro and in situ assays. In addition to ABHD6, the compound shows limited inhibitory effects on other enzymes tested in the same cell type..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	KT203, a selective and potent structural domain 6 (ABHD6) inhibitor of alpha/beta hydrolytic enzymes, exhibits potential antiviral and anti-inflammatory properties for pneumonia research.
Targets&IC50	ABHD6 (Neuro2A cells):0.31 nM

Chemical Properties

Molecular Weight	466.53
Formula	C₂₈H₂₆N₄O₃
Cas No.	1402612-64-9
Smiles	OC(=O)c1cccc(c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1Cc1ccccc1
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (171.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1435 mL	10.7174 mL	21.4348 mL	107.1742 mL
5 mM	0.4287 mL	2.1435 mL	4.2870 mL	21.4348 mL
10 mM	0.2143 mL	1.0717 mL	2.1435 mL	10.7174 mL
20 mM	0.1072 mL	0.5359 mL	1.0717 mL	5.3587 mL
50 mM	0.0429 mL	0.2143 mL	0.4287 mL	2.1435 mL
100 mM	0.0214 mL	0.1072 mL	0.2143 mL	1.0717 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc