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Anti-Angiopoietin-1 Antibody (5C751)
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Catalog No. TMAY-02623
Anti-Angiopoietin-1 Antibody (5C751) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (5C751) can be used in ELISA.
Anti-Angiopoietin-1 Antibody (5C751)
Anti-Angiopoietin-1 Antibody (5C751)
😃Good
Catalog No. TMAY-02623
Anti-Angiopoietin-1 Antibody (5C751) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (5C751) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μL | $199 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Angiopoietin-1 Antibody (5C751) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (5C751) can be used in ELISA. |
| Ig Type | Mouse IgG2b |
| Clone | 5C751 |
| Reactivity | Human |
| Specificity | Human Angiopoietin-1/ANGPT1 |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Angiopoietin-1 (rh Angiopoietin-1; TMPY-05435; NP_001137.2; Met1-Leu261 and Arg277-Phe498). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Angiopoietin-1 Protein (TMPY-05435) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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