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ZNRF3 Protein, Human, Recombinant (His)
(Synonyms: ZNRF3, Zinc/RING finger protein 3, RNF203, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, E3 ubiquitin-protein ligase ZNRF3) Copy Product InfoSynonyms: ZNRF3, Zinc/RING finger protein 3, RNF203, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, E3 ubiquitin-protein ligase ZNRF3
Catalog No. TMPH-01275 Copy Product Info
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $67 | 20 days | 20 days | |
| 10 μg | $107 | 20 days | 20 days | |
| 20 μg | $175 | 20 days | 20 days | |
| 50 μg | $268 | 20 days | 20 days | |
| 100 μg | $377 | 20 days | 20 days | |
| 200 μg | $688 | 20 days | 20 days | |
| 500 μg | $1,530 | 20 days | 20 days | |
| 1 mg | $2,860 | 20 days | 20 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | Q9ULT6 |
| Amino Acid | KETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDM |
| Construction | 56-219 aa |
| Protein Purity | > 95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 6% Trehalose, pH 7.4 |
| Reconstitution | Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | ZNRF3, Zinc/RING finger protein 3, RNF203, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, E3 ubiquitin-protein ligase ZNRF3 |
| Research Background |
| Molecular Weight | 20.4 kDa (predicted) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: ZNRF3 Protein, Human, Recombinant (His) chemical structure | ZNRF3 Protein, Human, Recombinant (His) molecular weight
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