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Anti-NPSR1 Polyclonal Antibody is a Rabbit antibody targeting NPSR1. Anti-NPSR1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $222 | 7-10 days | |
100 μL | $373 | 7-10 days | |
200 μL | $529 | 7-10 days |
Description | Anti-NPSR1 Polyclonal Antibody is a Rabbit antibody targeting NPSR1. Anti-NPSR1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
Synonyms | VRR1, VRR 1, Vasopressin receptor related receptor 1, PGR14, PGR 14, NPSR1, NPSR 1, NPSR, nps receptor, Neuropeptide S receptor 1, Neuropeptide S receptor, MVTR, GPRA, GPR154, GPR 154, G protein coupled receptor PGR14, G protein coupled receptor for asthma susceptibility, G protein coupled receptor 154, ASRT2 |
Ig Type | IgG |
Reactivity | (predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep) |
Application | |
Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Cell Membrane and Cytoplasmic |
Tissue Specificity | Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epitheli |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine signaling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2). |
Immunogen | KLH conjugated synthetic peptide: human NPSR1 |
Antigen Species | Human |
Gene Name | NPSR1 |
Gene ID | |
Protein Name | Neuropeptide S receptor |
Uniprot ID | |
Biology Area | Macrophage / Inflamm.,More GPCR,GPCR |
Function | Neuropeptide S receptor 1 (GPR154) is a receptor for Neuropeptide S. It is expressed on the epithelia of several organs including the intestine, and appears to be upregulated in inflammation. It is upregulated in macrophages after antigen challenge and is involved in the pathogenesis of asthma and other IgE-mediated diseases. |
Molecular Weight | Theoretical: 43 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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