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2-Aminoethanethiol

Name: 2-Aminoethanethiol
Brand: TargetMol
SKU: T1080
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1080Cas No. 60-23-1

Alias β-Mercaptoethylamine, β-MEA, Cysteamine, 2-Mercaptoethylamine

2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.

2-Aminoethanethiol

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Purity: 98.9%

Catalog No. T1080Alias β-Mercaptoethylamine, β-MEA, Cysteamine, 2-MercaptoethylamineCas No. 60-23-1

2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$45	In Stock	In Stock
1 g	$53	-	In Stock
5 g	$123	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.9%

Color:White to Purple

Resource Download

COA HNMR

Product Introduction

2-Aminoethanethiol AI Summary

2-Aminoethanethiol exhibits a wide range of bioactivities and effects. At 250 µM, it impacts intracellular GSH (Glutathione) content in human macrophage-derived monocytes, resulting in a GSH level of 200.0. It facilitates cysteamine excretion in urine and feces and has an LD50 of 450.0 mg/kg in mice. When administered intraperitoneally at 225 mg/kg, it improves survival rates post-irradiation. 2-Aminoethanethiol inhibits Plasmodium falciparum with an IC50 of 200,000.0 nM and shows antiviral activity against HIV-1 with EC50 values of 41,600.0 nM and 53,700.0 nM depending on the assay. It cleaves single-stranded PNA and PNA:DNA duplexes efficiently and inhibits lipid peroxidation in rat hepatic microsomal membrane lipids at a concentration of 1 µM, with a 37.0% inhibition rate. Toxicity studies in Fischer 344 rats show 80.0% mortality at 1.6 mmol/kg subcutaneously, along with gastrointestinal toxicity and body weight decrease. 2-Aminoethanethiol inhibits human OCT1 uptake in HEK293 cells and shows a variety of other bioactivities, including effects on mitochondrial dynamics, thyroid stimulating hormone receptor activation, and inhibition of various enzymes and receptors. It was evaluated for drug-induced liver injury using the DILIps training set, showing no hepatic side effects across multiple assays and moderate acute liver toxicity in clinical trials. It inhibits human BSEP with an IC50 of 331,000.0 nM and demonstrates anti-inflammatory activity in Balb/C mice by reducing carrageenan-induced hind paw edema by 15.0% at 0.15 mmol/kg. No significant inhibition of histone lysine methyltransferases G9a and GLP was observed within the studied concentration range. Furthermore, 2-Aminoethanethiol possesses antioxidant properties against various radicals and shows moderate antiviral activity against SARS-CoV-2. It also exhibits specific HDAC6 inhibitory activity depending on the peptide substrate used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
Synonyms	β-Mercaptoethylamine, β-MEA, Cysteamine, 2-Mercaptoethylamine

Chemical Properties

Molecular Weight	77.15
Formula	C₂H₇NS
Cas No.	60-23-1
Smiles	NCCS
Relative Density.	0.973 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 194.4 mM, Sonication is recommended.

H2O: 194.4 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	12.9618 mL	64.8088 mL	129.6176 mL	648.0881 mL
5 mM	2.5924 mL	12.9618 mL	25.9235 mL	129.6176 mL
10 mM	1.2962 mL	6.4809 mL	12.9618 mL	64.8088 mL
20 mM	0.6481 mL	3.2404 mL	6.4809 mL	32.4044 mL
50 mM	0.2592 mL	1.2962 mL	2.5924 mL	12.9618 mL
100 mM	0.1296 mL	0.6481 mL	1.2962 mL	6.4809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc