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9-cis-Retinoic Acid

Name: 9-cis-Retinoic Acid
Brand: TargetMol
SKU: T21497
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21497Cas No. 5300-03-8

Alias Alitretinoin

9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.

9-cis-Retinoic Acid

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Purity: 99.90%

Catalog No. T21497Alias AlitretinoinCas No. 5300-03-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$78	-	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$396	-	In Stock
50 mg	$619	-	In Stock
100 mg	$993	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.
In vitro	In CA 9-22 and NA cells, 9-cis-Retinoic acid (1 μM, 10 μM; 0 day, 1 day, 3 days, 5 days) significantly decreased proliferation[1].
In vivo	In male C57BL/6J mice (6-8 weeks old; 19-22 g), following bile duct ligation, treatment with 9-cis-Retinoic Acid (1 mg/kg; intravenous injection; once daily; for 10 days) significantly decreased serum ALT and AST levels and alleviated hepatic necrosis[3].
Synonyms	Alitretinoin

Chemical Properties

Molecular Weight	300.44
Formula	C₂₀H₂₈O₂
Cas No.	5300-03-8
Smiles	C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (49.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3285 mL	16.6423 mL	33.2845 mL	166.4226 mL
5 mM	0.6657 mL	3.3285 mL	6.6569 mL	33.2845 mL
10 mM	0.3328 mL	1.6642 mL	3.3285 mL	16.6423 mL
20 mM	0.1664 mL	0.8321 mL	1.6642 mL	8.3211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc