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mGluR3 modulator-1

Name: mGluR3 modulator-1
Brand: TargetMol
SKU: T9970
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9970Cas No. 374548-18-2

Alias 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.

mGluR3 modulator-1

🥰Excellent

Purity: 98.99%

Catalog No. T9970Alias 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrileCas No. 374548-18-2

Pack Size	Price	Availability
5 mg	$58	In Stock
10 mg	$88	In Stock
25 mg	$160	In Stock
50 mg	$238	In Stock
100 mg	$349	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

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Batch Information

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Purity:98.99%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.
Synonyms	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Chemical Properties

Molecular Weight	271.36
Formula	C₁₆H₂₁N₃O
Cas No.	374548-18-2
Smiles	CCC1=NC(N2CCOCC2)=C(C#N)C2=C1CCCC2
Color	Cyan
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (202.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6851 mL	18.4257 mL	36.8514 mL	184.2571 mL
5 mM	0.7370 mL	3.6851 mL	7.3703 mL	36.8514 mL
10 mM	0.3685 mL	1.8426 mL	3.6851 mL	18.4257 mL
20 mM	0.1843 mL	0.9213 mL	1.8426 mL	9.2129 mL
50 mM	0.0737 mL	0.3685 mL	0.7370 mL	3.6851 mL
100 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc