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mGluR3 modulator-1

Name: mGluR3 modulator-1
Brand: TargetMol
SKU: T9970
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9970Cas No. 374548-18-2

Alias 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.

mGluR3 modulator-1

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Purity: 98.99%

Catalog No. T9970Alias 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrileCas No. 374548-18-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$58	-	In Stock
10 mg	$88	-	In Stock
25 mg	$160	-	In Stock
50 mg	$238	-	In Stock
100 mg	$349	-	In Stock
1 mL x 10 mM (in DMSO)	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

mGluR3 modulator-1 AI Summary

mGluR3 modulator-1 is a bioactive inhibitor exhibiting diverse inhibitory properties across multiple biological targets. It has demonstrated efficacy against Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 31622.8 nM and Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 35481.3 nM. Additionally, it inhibits AmpC Beta-Lactamase with a significant potency of 631.0 nM and DNA Polymerase Beta at 3981.1 nM. The compound also interacts with Methylated Histone Tails (potency 89125.1 nM) and shows inhibition in a TGF-b Cytotox Counterscreen (19952.6 nM). Further, it inhibits Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) with a potency of 44668.4 nM and Hepatitis C Virus (HCV) at 4466.8 nM. Notably, mGluR3 modulator-1 acts as an inverse agonist of the GLP-1 Receptor (12589.3 nM) and has potential antiviral activity against the Foot and Mouth Disease Virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.
Synonyms	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

Chemical Properties

Molecular Weight	271.36
Formula	C₁₆H₂₁N₃O
Cas No.	374548-18-2
Smiles	CCC1=NC(N2CCOCC2)=C(C#N)C2=C1CCCC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (202.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6851 mL	18.4257 mL	36.8514 mL	184.2571 mL
5 mM	0.7370 mL	3.6851 mL	7.3703 mL	36.8514 mL
10 mM	0.3685 mL	1.8426 mL	3.6851 mL	18.4257 mL
20 mM	0.1843 mL	0.9213 mL	1.8426 mL	9.2129 mL
50 mM	0.0737 mL	0.3685 mL	0.7370 mL	3.6851 mL
100 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc