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Omaciclovir

Name: Omaciclovir
Brand: TargetMol
SKU: T28234
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28234Cas No. 124265-89-0

Alias H2G, H 2G, ABT-091, ABT091, ABT 091, (-)-2HM-HBG

Omaciclovir (ABT-091) is a selective herpesvirus herpesvirus replication inhibitor and a nucleoside analog with antiviral activity for the study of herpesvirus infections.

Omaciclovir

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Purity: 99.46%

Catalog No. T28234Alias H2G, H 2G, ABT-091, ABT091, ABT 091, (-)-2HM-HBGCas No. 124265-89-0

Omaciclovir (ABT-091) is a selective herpesvirus herpesvirus replication inhibitor and a nucleoside analog with antiviral activity for the study of herpesvirus infections.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock
1 mL x 10 mM (in DMSO)	$29	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.46%

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COA

Product Introduction

Bioactivity

Description	Omaciclovir (ABT-091) is a selective herpesvirus herpesvirus replication inhibitor and a nucleoside analog with antiviral activity for the study of herpesvirus infections.
Targets&IC50	MeWo VZ30:0.016 μM (EC50), MeWo VZV-32:0.015 μM (EC50), MRC5 VZV-32:0.72 μM (EC50), MeWo VZ11:0.035 μM (EC50), MeWo Emily:0.047 μM (EC50), MeWo Molly:0.048 μM (EC50), MRC5 Molly:0.62 μM (EC50)
In vitro	Omaciclovir is a nucleoside analog with inhibitory activity in vitro against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus, and human herpesvirus 6. Additionally, Omaciclovir demonstrates significant antiviral activity against various human herpesviruses, with half-maximal effective concentrations (EC50) of EC50=0.72 μM, EC50=0.62 μM, EC50=0.015 μM, EC50=0.048 μM, EC50=0.047 μM, EC50=0.035 μM, and EC50=0.016 μM in MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively. [1]
In vivo	Omaciclovir has also shown efficacy in monkeys infected with simian varicella virus. [1]
Synonyms	H2G, H 2G, ABT-091, ABT091, ABT 091, (-)-2HM-HBG

Chemical Properties

Molecular Weight	253.26
Formula	C₁₀H₁₅N₅O₃
Cas No.	124265-89-0
Smiles	C([C@@H](CCO)CO)N1C2=C(N=C1)C(=O)N=C(N)N2
Relative Density.	1.68g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (789.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (19.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9485 mL	19.7426 mL	39.4851 mL	197.4256 mL
5 mM	0.7897 mL	3.9485 mL	7.8970 mL	39.4851 mL
10 mM	0.3949 mL	1.9743 mL	3.9485 mL	19.7426 mL
20 mM	0.1974 mL	0.9871 mL	1.9743 mL	9.8713 mL
50 mM	0.0790 mL	0.3949 mL	0.7897 mL	3.9485 mL
100 mM	0.0395 mL	0.1974 mL	0.3949 mL	1.9743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc