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Omaciclovir

Name: Omaciclovir
Brand: TargetMol
SKU: T28234
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28234Cas No. 124265-89-0

Alias H2G, H 2G, ABT-091, ABT091, ABT 091, (-)-2HM-HBG

Omaciclovir (ABT-091) is a selective herpesvirus herpesvirus replication inhibitor and a nucleoside analog with antiviral activity for the study of herpesvirus infections.

Omaciclovir

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Purity: 99.46%

Catalog No. T28234Alias H2G, H 2G, ABT-091, ABT091, ABT 091, (-)-2HM-HBGCas No. 124265-89-0

Omaciclovir (ABT-091) is a selective herpesvirus herpesvirus replication inhibitor and a nucleoside analog with antiviral activity for the study of herpesvirus infections.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock
1 mL x 10 mM (in DMSO)	$29	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.46%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Omaciclovir (ABT-091) is a selective herpesvirus herpesvirus replication inhibitor and a nucleoside analog with antiviral activity for the study of herpesvirus infections.
Targets&IC50	MeWo VZ30:0.016 μM (EC50), MeWo VZ11:0.035 μM (EC50), MRC5 VZV-32:0.72 μM (EC50), MRC5 Molly:0.62 μM (EC50), MeWo Emily:0.047 μM (EC50), MeWo Molly:0.048 μM (EC50), MeWo VZV-32:0.015 μM (EC50)
In vitro	Omaciclovir is a nucleoside analog with inhibitory activity in vitro against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus, and human herpesvirus 6. Additionally, Omaciclovir demonstrates significant antiviral activity against various human herpesviruses, with half-maximal effective concentrations (EC50) of EC50=0.72 μM, EC50=0.62 μM, EC50=0.015 μM, EC50=0.048 μM, EC50=0.047 μM, EC50=0.035 μM, and EC50=0.016 μM in MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively. [1]
In vivo	Omaciclovir has also shown efficacy in monkeys infected with simian varicella virus. [1]
Synonyms	H2G, H 2G, ABT-091, ABT091, ABT 091, (-)-2HM-HBG

Chemical Properties

Molecular Weight	253.26
Formula	C₁₀H₁₅N₅O₃
Cas No.	124265-89-0
Smiles	C([C@@H](CCO)CO)N1C2=C(N=C1)C(=O)N=C(N)N2
Relative Density.	1.68g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (789.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (19.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9485 mL	19.7426 mL	39.4851 mL	197.4256 mL
5 mM	0.7897 mL	3.9485 mL	7.8970 mL	39.4851 mL
10 mM	0.3949 mL	1.9743 mL	3.9485 mL	19.7426 mL
20 mM	0.1974 mL	0.9871 mL	1.9743 mL	9.8713 mL
50 mM	0.0790 mL	0.3949 mL	0.7897 mL	3.9485 mL
100 mM	0.0395 mL	0.1974 mL	0.3949 mL	1.9743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc