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(Rac)-Byakangelicin

Name: (Rac)-Byakangelicin
Brand: TargetMol
SKU: T3801
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3801Cas No. 19573-01-4

Alias Byakangelicin, Bjakangelicin, Bjacangelicin, Biacangelicin, 7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-

(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.

(Rac)-Byakangelicin

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Purity: 99.94%

Catalog No. T3801Alias Byakangelicin, Bjakangelicin, Bjacangelicin, Biacangelicin, 7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-Cas No. 19573-01-4

(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$93	In Stock	In Stock
10 mg	$152	In Stock	In Stock
25 mg	$245	In Stock	In Stock
50 mg	$368	In Stock	In Stock
100 mg	$547	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White to Yellow

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COA

Product Introduction

(Rac)-Byakangelicin AI Summary

(Rac)-Byakangelicin exhibits diverse bioactivities including inhibition of histamine release in ddY mouse peritoneal cavity fluid, with a peak inhibitory effect of 105.4% at a dose of 10 mg/kg, which decreases to 57.0% at 25 mg/kg. It inhibits human Jumonji Domain Containing 2E (JMJD2E), AmpC Beta-Lactamase, HP1-beta Chromodomain interactions with methylated histone tails, and USP1/UAF1. It also acts as an agonist for cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1) and inhibits MBNL1-poly(CUG) RNA binding. (Rac)-Byakangelicin prevents Marburg Virus binding or entry into cells and induces synthetic lethality in tumor cells producing 2HG. It inhibits recombinant human BACE1 with an IC50 of 219700.0 nM, exhibiting Ki values of 55000.0 nM and 6200.0 nM for the enzyme-inhibitor and enzyme-substrate-inhibitor complexes, respectively. Additionally, it reduces ROS accumulation in human HepG2 cells with a 57.9% activity at 10 uM and confers hepatoprotective activity by enhancing HepG2 cell viability by 46.5% under H2O2-induced stress at the same concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.
Synonyms	Byakangelicin, Bjakangelicin, Bjacangelicin, Biacangelicin, 7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-

Chemical Properties

Molecular Weight	334.32
Formula	C₁₇H₁₈O₇
Cas No.	19573-01-4
Smiles	COc1c2ccoc2c(OCC(O)C(C)(C)O)c2oc(=O)ccc12
Relative Density.	1.373g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (74.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9911 mL	14.9557 mL	29.9115 mL	149.5573 mL
5 mM	0.5982 mL	2.9911 mL	5.9823 mL	29.9115 mL
10 mM	0.2991 mL	1.4956 mL	2.9911 mL	14.9557 mL
20 mM	0.1496 mL	0.7478 mL	1.4956 mL	7.4779 mL
50 mM	0.0598 mL	0.2991 mL	0.5982 mL	2.9911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc