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PRE-084 hydrochloride

🥰Excellent
Catalog No. T3198LCas No. 75136-54-8

PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).

PRE-084 hydrochloride
Other Forms of PRE-084 hydrochloride:
Pre-084T3198138847-85-5
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PRE-084 hydrochloride

🥰Excellent
Purity: 99.54%
Catalog No. T3198LCas No. 75136-54-8
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$37In StockIn Stock
10 mg$59In StockIn Stock
25 mg$123In StockIn Stock
50 mg$218In StockIn Stock
100 mg$389In StockIn Stock
200 mg$595-In Stock
1 mL x 10 mM (in DMSO)$66In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.54%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
Chemical Properties
Molecular Weight353.88
FormulaC19H28ClNO3
Cas No.75136-54-8
SmilesCl.O=C(OCCN1CCOCC1)C1(CCCCC1)c1ccccc1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 31 mg/mL (87.6 mM), Sonication is recommended.
H2O: 35.4 mg/mL (100.03 mM), Sonication and heating are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.8258 mL14.1291 mL28.2582 mL141.2908 mL
5 mM0.5652 mL2.8258 mL5.6516 mL28.2582 mL
10 mM0.2826 mL1.4129 mL2.8258 mL14.1291 mL
20 mM0.1413 mL0.7065 mL1.4129 mL7.0645 mL
50 mM0.0565 mL0.2826 mL0.5652 mL2.8258 mL
H2O
1mg5mg10mg50mg
100 mM0.0283 mL0.1413 mL0.2826 mL1.4129 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

σ1SigmareceptorSigma receptorSigma ReceptorProtein kinase BPRE-084 HydrochloridePRE084 HydrochloridePRE084 hydrochloridePRE-084PRE084PRE 084 hydrochloridePRE 084 HydrochloridePRE 084PKBNOSNO SynthaseNitric oxide synthasesneuroprotectionneurological diseasesInhibitorinhibitcortical cellsAlzheimer's diseaseALSAkt
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