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GAC0001E5

Name: GAC0001E5
Brand: TargetMol
SKU: T68323
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68323Cas No. 927969-67-3

GAC0001E5 (1E5) is a dual LXR inverse agonist and degrader (IC50 = 5.4-9.1 μM in pancreatic cancer cells). It inhibits tumor growth and induces apoptosis by promoting LXRα/β degradation and suppressing transcriptional activity.

GAC0001E5

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Purity: 98.89%

Catalog No. T68323Cas No. 927969-67-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$970	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.89%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GAC0001E5 (1E5) is a dual LXR inverse agonist and degrader (IC50 = 5.4-9.1 μM in pancreatic cancer cells). It inhibits tumor growth and induces apoptosis by promoting LXRα/β degradation and suppressing transcriptional activity.
In vitro	In Western Blot, GAC0001E5 (1E5) reduced LXRα/β protein levels. It inhibited growth in AsPC-1, MiaPaCa-2, and BxPC-3 cells (IC50 = 8.0, 5.4, and 9.1 μM) and downregulated ABCA1 via qPCR[1].

Chemical Properties

Molecular Weight	331.29
Formula	C₁₇H₁₂F₃N₃O
Cas No.	927969-67-3
Smiles	O=C1N=C(NC2=CC=CC(=C2)C(F)(F)F)NC(=C1)C=3C=CC=CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (301.85 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0185 mL	15.0925 mL	30.1850 mL	150.9252 mL
5 mM	0.6037 mL	3.0185 mL	6.0370 mL	30.1850 mL
10 mM	0.3019 mL	1.5093 mL	3.0185 mL	15.0925 mL
20 mM	0.1509 mL	0.7546 mL	1.5093 mL	7.5463 mL
50 mM	0.0604 mL	0.3019 mL	0.6037 mL	3.0185 mL
100 mM	0.0302 mL	0.1509 mL	0.3019 mL	1.5093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc