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rel-(1R,2R)-Vesamicol Hydrochloride
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Catalog No. T22486Cas No. 120447-62-3
Alias (±)-AH5183 hydrochloride
rel-(1R,2R)-Vesamicol Hydrochloride is an isomer of Vesamicol Hydrochloride and can be employed in biochemical experiments.
rel-(1R,2R)-Vesamicol Hydrochloride
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Purity: 99.88%
Catalog No. T22486Alias (±)-AH5183 hydrochlorideCas No. 120447-62-3
rel-(1R,2R)-Vesamicol Hydrochloride is an isomer of Vesamicol Hydrochloride and can be employed in biochemical experiments.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | In Stock | In Stock | |
| 5 mg | $52 | In Stock | In Stock | |
| 10 mg | $79 | In Stock | In Stock | |
| 25 mg | $158 | In Stock | In Stock | |
| 50 mg | $235 | In Stock | In Stock | |
| 100 mg | $347 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.88%
Appearance:Solid
Color:White
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Product Introduction
rel-(1R,2R)-Vesamicol Hydrochloride AI Summary
rel-(1R,2R)-Vesamicol Hydrochloride exhibits a diverse range of bioactivities. It acts as a potent agonist of the Thyroid Stimulating Hormone Receptor with an efficacy of 100.0 nM and modulates lipid storage in Drosophila S3 Cells with a potency of 2592.9 nM. Additionally, it inhibits several targets with varying potencies: Firefly Luciferase (25118.9 nM), Schistosoma Mansoni Peroxiredoxins (89125.1 nM), Histone Lysine Methyltransferase G9a (89125.1 nM), BAZ2B (89125.1 nM), HP1-beta Chromodomain interactions with methylated histone tails (79432.8 nM), and Polymerase Iota (89125.1 nM). Remarkably, it induces DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells at potencies of 4.1 nM and 231.1 nM, respectively.
In addition to these activities, rel-(1R,2R)-Vesamicol Hydrochloride demonstrates notable antiviral properties against SARS-CoV-2. It inhibits the virus-induced cytotoxicity in Caco-2 cells by 19.41% at 10 µM after 48 hours and inhibits SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition rate of 13.46%. Moreover, it exhibits an inhibition rate of 0.36% against SARS-CoV-2 induced cytotoxicity in VERO-6 cells under similar conditions.
rel-(1R,2R)-Vesamicol Hydrochloride also shows antifungal activity, inhibiting Candida albicans by 3.46% but exhibiting a negative inhibition rate of -7.38% against Cryptococcus neoformans. Its antibacterial efficacy varies, with inhibition rates of 1.48% against Escherichia coli, 4.06% against Klebsiella pneumoniae, 10.24% against Pseudomonas aeruginosa, 20.4% against Acinetobacter baumannii, and 14.8% against Staphylococcus aureus MRSA..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | rel-(1R,2R)-Vesamicol Hydrochloride is an isomer of Vesamicol Hydrochloride and can be employed in biochemical experiments. |
| Targets&IC50 | Acetylcholine transport (vesicular):2 nM (Ki), σ2 receptor:34 nM (Ki), σ1 receptor:26 nM (Ki) |
| Synonyms | (±)-AH5183 hydrochloride |
| Molecular Weight | 295.85 |
| Formula | C17H26ClNO |
| Cas No. | 120447-62-3 |
| Smiles | Cl.OC1CCCCC1N1CCC(CC1)C1=CC=CC=C1 |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 5.92 mg/mL, Sonication is recommended. DMSO: 18.7 mg/mL (63.21 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.76 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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